Applications are invited for a postdoctoral researcher in the Laboratory of Dr. Yogesh Kulathu to study the mechanisms by which T cell biology and immune responses are regulated by the ubiquitin system.

The Kulathu lab uses a multidisciplinary approach in their research and employ techniques ranging from structural biology and biophysics to cell biology. The aims of the projects available in the lab are to explore the functional roles of components of the ubiquitin system in regulating T cell function. We are also interested in investigating underlying mechanisms using genetic screens, reconstitution systems and in vivo reporter models that the successful candidate will develop and apply during this project.

The candidate should have a strong academic track record, background and experience in biochemistry. It is expected that the candidate will develop and apply a broad range of techniques to pursue the research objectives and work on multiple projects. The project will involve using the cutting-edge facilities in biochemistry, cell biology, in vivo models, high-resolution microscopy and proteomics available within the School of Life Sciences.

The Kulathu Lab are a fun and culturally diverse group of students and postdocs. We provide a learning, collaborative and supportive environment to work in. Research in this lab is supported by the Medical Research Council (MRC), European Research Council (ERC) Starting Grant, Lister Research Prize and EMBO Young Investigator Programme.

This position is available Full-Time, Fixed Term for 3 years in the first instance. Informal enquiries may be directed to ykulathu@dundee.ac.uk

MRC Protein Phosphorylation and Ubiquitylation Unit (PPU):

This project will be performed in the MRC Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU), based within the School of Life Sciences at the University of Dundee. The MRC-PPU is in a beautiful location overlooking the estuary of the River Tay and embedded within the School of Life Sciences at the University of Dundee which is one of the premier Life Sciences research centres in the world.

Candidate requirements:

• PhD (or final stages of PhD) in a relevant biological subject with research experience in protein biochemistry and cell biology or proteomics.

• Strong academic track record with at least one good quality first author publication in peer-reviewed journals.

• Ability to work independently, but capable of interacting well within a group

• Excellent communication skills and proficiency in English

Appointment as a Postdoctoral Research Assistant on the Grade 7 salary scale is dependent upon you having been awarded a PhD. An appointment may be considered if you are shortly expected to be awarded a PhD. The initial appointment will be made as a Research Assistant on the Training Grade 7 salary scale (Spinal Point 28, £31,302).

Apply Here: https://www.jobs.dundee.ac.uk/fe/tpl_uod01.asp?s=4A515F4E5A565B1A&jobid=103509,2386710286&key=142051726&c=51831248211556&pagestamp=seifxexfwwlxfiwoqj

The diversity of our staff and students helps to make the University of Dundee a UK university of choice for undergraduate, postgraduate and distance learning. Family friendly policies, staff networks for BME, Disabled and LGBT staff, membership of Athena SWAN, the ECU Race Equality Charter and Stonewall as well a full range of disability services, create an enjoyable and inclusive place to work.

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Reference Number SLSC0624
Closing Date Sat 10 Aug 2019
Salary Grade 7 (£32,236 - £39,609)

Post-doctoral Position in the laboratory of Prof Miratul Muqit to decipher cell signalling pathways in Parkinson’s disease funded by a Wellcome Trust Senior Research Fellowship.

The aim of the projects will be to better understand the regulation of mitochondrial autophagy by the PINK1 kinase and Parkin ubiquitin E3 ligase that are mutated in familial forms of Parkinson’s disease. These studies have the potential to transform our understanding of the molecular basis of Parkinson’s disease-linked neurodegeneration and the candidate’s research may ultimately be exploited to improve diagnostic and therapeutic options for patients.

The successful applicant will have access to state-of-the-art technologies in biochemistry, proteomics, genome editing, cell biology, and transgenic mouse models to uncover new fundamental knowledge on these key molecules.

The laboratory is part-funded by EMBO and successful applicants will have access to EMBO sponsored opportunities for training and self-development. The MRC unit also collaborates with three major pharmaceutical companies that support the Division of Signal Transduction Therapy that provides opportunities for interaction with industry and potential exploitation of new discoveries made in the lab

The position is available for 3 years in the first instance.

Candidate requirements:

- PhD with an outstanding track record and at least one first authored publication in an internationally recognised peer-reviewed journal.
- Strong background in any one of Cell Signalling, Neurobiology, Molecular Biology, and Biochemistry would be preferable.
- Capable of working in a team, but able to plan and work independently.
- Excellent communication skills and proficiency in English.

Appointment as a Postdoctoral Research Assistant on the Grade 7 salary scale is dependent upon you having been awarded a PhD.

An appointment may be considered if you are shortly expected to be awarded a PhD.

The initial appointment will be made as a Research Assistant on the Training Grade 7 salary scale (Spinal Point 28, £31,302).

For informal enquiries please contact Miratul Muqit m.muqit@dundee.ac.uk.

For details on the Muqit lab please visit http://www.ppu.mrc.ac.uk/research/?pid=11.

The Muqit lab is based in the MRC Protein Phosphorylation and Ubiquitylation Unit (MRC PPU), one of the world’s most renowned centres for research on protein phosphorylation and ubiquitylation (http://www.ppu.mrc.ac.uk) and is an exciting and collaborative research environment, equipped to the highest international standards. The major aims of the MRC-PPU are to advance understanding of the role of protein phosphorylation and ubiquitylation in cell regulation and human disease; to facilitate the development of drugs to treat diseases caused by abnormalities in phosphorylation; and to generate reagents and improve technologies. Another key remit of the MRC-PPU is to train the next generation of scientists who will advance our understanding in this crucial area of medical research. School of Life Sciences at the University of Dundee is one of the premier research centres in the world and was recently assessed as the top UK University for Life Sciences research in the 20!
14 Research Excellence Framework (REF).

The diversity of our staff and students helps to make the University of Dundee a UK university of choice for undergraduate, postgraduate and distance learning. Family friendly policies, staff networks for BME, Disabled and LGBT staff, membership of Athena SWAN, the ECU Race Equality Charter and Stonewall as well a full range of disability services, create an enjoyable and inclusive place to work.

Application:
To apply on-line please visit: www.dundee.ac.uk/jobs. If you are unable to apply on-line please contact Human Resources on (01382) 386209 (answering machine) for an application pack. Please quote reference number SLSC0624.

The University of Dundee is committed to equal opportunities and welcomes applications from all sections of the community.

The University of Dundee is a diverse community and is committed to equality of opportunity for all by providing a supportive, flexible and inclusive working environment. We have family friendly policies (including flexible working and childcare vouchers), staff groups for LGBT and BME; and prayer room facilities.

The University of Dundee has received the Athena SWAN Bronze Award which recognises the promotion of gender equality and has made further commitment to advancing inclusive culture which supports and encourages all under-represented groups.

The University of Dundee is a Scottish Registered Charity, No. SC015096.

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Postdoctoral Training Immunology and Autoimmune Disease

A postdoc position is immediately available in the Vilen lab at the
University of North Carolina at Chapel Hill.

Our lab focuses on the mechanisms underlying immune dysfunction in autoimmune disease. We identified that in systemic lupus erythematosus (SLE), defects in lysosome acidification reduce degradation of IgG-immune complexes that enter myeloid cells by phagocytosis. This defect leads to multiple pathologies associated with murine SLE. Our recently funded NIH/DOD grants propose translational studies to assess whether lysosome dysfunction underlies human SLE, and studies to assess whether restoring lysosome function prevents onset or attenuates progression of disease in mice. Other goals seek to define the molecular and genetic events that drive lysosome dysfunction. Thus, projects are available to study murine or human aspects of lupus. Detailed research information is available on our websites: https://www.vilenlab.com/ and https://www.med.unc.edu/microimm/directory/barbara-vilen-phd/.

Successful candidates require a background in immunology, experiences in murine models or human translational research and good English speaking and writing skills. A sound track-record of publishing, and strong internal motivation are essential. Experiences in flow cytometry/microscopy (multicolor, multiple cell types), animal models (injection, bleeding, organ processing) are preferred. Salary is based on years of quality experience. Time period is variable, but funding is in-place for 4 years.

UNC-Chapel Hill is situated between the Blue Ridge Mountains and the NC Beaches, close to Durham, Raleigh, and Research Triangle Park. It has an excellent, collaborative research environment.

Please send CV including contact information for three references,
and cover letter (optional) to:

Barbara Vilen, Ph.D. (barb_vilen@med.unc.edu)
Department of Microbiology & Immunology, 6110 Marsico Hall
University of North Carolina at Chapel Hill

ポスドク募集（免疫学、自己免疫疾患）

Vilen labではポスドク一名を急ぎ募集します。

私たちの研究室では、自己免疫疾患における免疫破綻機構の解明に焦点をあてて研究をおこなっています。私たちは、全身性エリテマトーデス(SLE)において、リソソーム酸化の異常により、ミエロイド系細胞に貪食されたIgG結合免疫複合体の分解が減少することを突き止めました。この異常によりSLEモデルマウスにおける様々な病態が引き起こされます。
私たちは最近NIH/DODより、ヒトのSLEにおけるリソソーム機能不全の有無や、リソソーム機能の補填によりモデルマウスにおけるSLEの発症や増悪が抑制できるかを調べることを目的としたトランスレーショナルグラントを獲得しました。その他、リソソーム機能不全を引き起こす分子生物学、遺伝学的メカニズムの解明も目的としています。そのため、このプロジェクトではマウスSLEとヒトSLEの双方が研究可能です。詳しい研究内容に関してはこちらのサイトをご覧ください：
https://www.vilenlab.com/
https://www.med.unc.edu/microimm/directory/barbara-vilen-phd/

応募資格：免疫学、マウスモデルやヒトトランスレーショナルリサーチに従事した経験のある方で、英語でのライティングや会話が可能な方。研究業績が豊富な方、強いモチベーションのある方を歓迎します
経験：フローサイトメトリーや蛍光顕微鏡、基本的なマウスの取り扱い
待遇：NIHのポスドク給与規定に準じます
期間：基本は4年ですが、相談に応じます
応募書類：
１：CV
２：3人の推薦者の連絡先
３：過去の研究、今後の展望などを記したカバーレター（オプション）
応募先：Barbara Vilen, Ph.D. (barb_vilen@med.unc.edu)

ノースカロライナ大学チャペルヒル校はBlue Ridge Mountains と NC Beaches　の間に位置し、Durham, Raleighとリサーチトライアングルパークを形成しています。デューク大学やノースカロライナ州立大学、National Institute of Environmental Health Sciences (NIEHS)との素晴らしいコラボレーションが可能なエリアです。

ご応募お待ちしております！

Barbara Vilen, Ph.D. (barb_vilen@med.unc.edu)
Department of Microbiology & Immunology, 6110 Marsico Hall
University of North Carolina at Chapel Hill

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A post-doctoral position is available immediately in the Wei lab at Dept. of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School. The lab’s major focus is on understanding how aberrant cell signaling pathways including ubiquination and phosphorylation events drive tumorigenesis. More specifically, the lab explores mechanistically how aberrancies in Ubiquitin E3 ligase APC (Gao et at Nature Cell Biology 11: 397, 2009; Wan et al, Molecular Cell 44: 721, 2011; Wan et al, Developmental Cell 29:377, 2014; Wan et al, Cancer Discovery 7:424, 2017) and SCF or other Cullin-based E3 ligases (Inuzuka et al, Cancer Cell 18:147, 2010; Inuzuka et al, Nature 471:104, 2011; Gao et al, Molecular Cell 44: 290, 2011; Inuzuka et al, Cell 150: 179, 2012; Gan et al, Molecular Cell 59: 917, 2015; Shimizu et al, Science Signaling 2017; Dai et al, Nature Medicine 2017) activities contribute to cell cycle regulation and subsequent tumor formation, as well as how PTEN/Akt/mT!
OR signaling pathway governs tumorigenesis (Liu et al, Nature 508: 541, 2014; Liu et al, Cancer Discovery 5:1194, 2015; Guo et al, Science 353:929, 2016; Wang et al, Nature 545:365). We recently also defined cell cycle dependent regulation of PD-L1 that provides the rationale for combination therapy of CDK4/6 inhibitor with PD-1 blockade (Zhang et al, Nature 553:91-95, 2018). Future projects in the lab engage the use of biochemistry, molecular biology and genetic approaches, cell culture techniques and potentially mouse modeling. Therefore, energetic applicants with strong experimental background in biochemistry, molecular and cellular biology and/or genetics are encouraged to apply.

Dr. Wei is looking for self-motivated individuals to become involved in the challenging and rewarding environment of the laboratory. If interested, please send your CV/resume and three references to

Wenyi Wei, Ph.D.
Professor
Dept. of Pathology, Harvard Medical School
Beth Israel Deaconess Medical Center
CLS-637, 3 Blackfan Circle
Boston, MA 02115
Phone: (617) 735-2495
Email: wwei2@bidmc.harvard.edu

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アラバマ大学バーミングハム校 （UAB） Department of Psychiatry and Behavioral Neurobiology　ポスドク募集 -Circuits and Systems Neuroscience Research-

1. 概要
アラバマ大学バーミンハム校医学部 (Birmingham, USA) の丹羽研究室 (https://niwaorg.wordpress.com/) では、博士研究員（ポスドク）を1名募集いたします。
Niwa Lab (PI: 丹羽美苗) では、脳の発達・機能ならびに恒常性維持における内分泌－神経系メカニズムの解明に焦点をあてて研究を行います。
私たちの身体では、神経系、内分泌系、免疫系が生体機能を巧みに制御することで恒常性を動的に維持しています。精神疾患では、脳の発達過程において、こうした制御系へのストレス負荷が従来備わっていた遺伝・環境素因と相まって恒常性の維持機構を変容・破綻させ、成人初期に疾患を引き起こすと考えられます。しかしながら、その詳細なメカニズムは未だ不明であります。私たちは、細胞レベルから内分泌－脳神経サーキット、行動レベルに至るまで統合的な解析を進め、ストレス関連精神疾患の病因・病態生理の解明および将来的な予防・診断・治療方法の開発に貢献することを目指しています。

2. 職種・分野等
Postdoctoral Fellow: This person will perform behavioral assays, neurochemical assays including in vivo microdialysis, circuit mapping, and in vivo calcium imaging with a miniature epifluorescence microscope in conjunction with optogenetic manipulation in the neurobiology and neuroendocrinology of parenting, emotional, motivational, and social behaviors. One of our projects is currently supported by a 5-year R01 research grant from the National Institute of Mental Health to understand the role of adolescent stress in postpartum mood and cognition.

3. 応募資格
1) 上記の研究に興味と基礎研究経験のあるPh.D., M.D., M.D.-Ph.D.取得者、あるいは着任までに取得見込みの方。一報以上の筆頭著者論文を有する方、学位取得後3年以内の方を歓迎いたします。
2) 基本的な分子生物学、生化学、顕微鏡操作、マウス行動実験の手技が必要となりますが、これらの技術は必須ではありません。特に、マウスにおける神経活動操作 (オプトジェネティクス) ならびに神経活動測定 (電気生理、イメージング) の技術・実績のある方を歓迎いたします。
3) 英語による基本的コミュニケーション能力のあり、新しい分野を開拓したいという熱意のある方を希望いたします。

4．募集人員
1名

5．着任時期　(採用予定日)
2019年7月以降。個別の事情に対応いたします。

6．待遇給与等
米国NIHおよびUABの規定に従います。UABの規定に従いビザのサポートも致します。留学にあたってのフェローシップ取得のサポートも致します。PIは学振PD、海外学振、さきがけ、NIH K99キャリアデベロプメントグラント等に採択された経験があり、日米でのグラント獲得およびPIになるためのキャリアデベロプメントについて具体的なアドバイスができます。

7．提出書類
1) CV
2) これまでの研究概要、本研究への興味・意欲、今後の研究に対する展望
3) 推薦者2-3名の連絡先、応募者本人との関係
これらを一つのPDFファイルにし、丹羽美苗 (mniwa@uabmc.edu) 宛にe-mail にてご送付ください。

8．応募締め切り
ポストが埋まり次第締め切ります。

9．応募書類送付先、問い合わせ先
Minae Niwa （丹羽美苗）, Ph.D.
E-mail: mniwa@uabmc.edu

10.　備考、その他
バーミングハムは、アトランタから車で2-3時間の場所にあるアメリカ南東部に位置する街です。他のアメリカの大都市に比べて、住宅費が格段に安いので、比較的ゆとりのある生活ができると思います。
UABでは神経科学系の研究が活発に行われています。設備、共同研究、生活など恵まれた環境の中で、海外での研究に挑戦したい意欲の高い方の応募をお待ちしております。

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McEwen Stem Cell Institution, Ogawaラボポスドク募集
カナダトロントにありますUHN （ University Health Network）のMcEwen Stem Cell Institutionの小川研究室（PI:小川真一郎）では、ヒトES/iPS細胞由来内胚葉細胞、肝細胞を用いて、肝臓発生及び成熟化の過程における分子細胞学的機序の解明とともにそれを用いた再生医療研究に努めております。再生医療の研究に熱意があり、Translational researchに意欲のあるポスドク研究員を募集しております。興味のある方は是非ご連絡、ご応募をください。

募集内容　博士研究員　1名
応募の目安となる条件：
（１） 医歯薬、理学系分野の博士号
（２） ヒト多能性幹細胞の培養経験（必須ではないです、当研究室で勉強していただいても構いません。）。遺伝子改変マウスモデルを用いた研究経験あるいは CRISPR/Cas９などの遺伝子改変技術を用いた研究経験のある方、またはBioinformaticsを用いた研究経験がある方
（３） 共同研究を行う上で、協調性と熱意を持って研究に取り組まれる方
（４） 奨学金、グラント、フェローシップのサポートがおありの方、又は受けられる可能性のある方（必須ではありませんが、望ましい。）
待遇：当研究施設の規定に従います。１年ごとの契約更新ですが、数年在籍して主要論文を発表する意欲のある方を募集します。
採用時期：ビザ申請などの手続き完了後、なるべく早い時期を希望します。
応募方法：
（１） これまでの研究の概要、今後の研究抱負を記したカバーレター（A4 1-2枚：英語表記：日本語表記の追加も可）
（２） CV （英語表記）
（３） コンタクト可能な推薦者２－3名の名前と連絡先
（４） 上記を一つのPDFファイルにして shinichiro.ogawa@uhnresearch.caまでお送りください。
選考方法：書類選考、Skype等を用いた面接を行います。適任者採用次第締め切りとなります。

連絡先：小川真一郎
Shinichiro Ogawa MD, PhD
Affiliate Scientist,
McEwen Stem Cell Institute
University Health Network
MaRS Centre/PMCRT 8-701
101 College Street
Toronto, ON M5G 1L7 CANADA

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