Multiple Postdoctoral Positions of Gene Regulation, Bioinformatics and/or Cancer Biology

Job Description: Lineberger Comprehensive Cancer Center & the Department of Biochemistry, University of North Carolina at Chapel Hill (UNC) School of Medicine

Multiple postdoctoral associate research positions available for the highly motivated candidates with a fresh PHD training in molecular biology, biochemistry and cell biology to join the Lineberger Comprehensive Cancer Center and Department of Biochemistry, University of North Carolina at Chapel Hill (UNC) School of Medicine, USA. Our lab (webpage: http://www.gregwanglab.com) emphasizes on mechanistic understandings of gene regulation, chromatin, stem cells, and human disease notably cancer. We have recently published our findings on various gene regulatory mechanisms, including those related to DNA methyltransferase and histone modifying enzymes, at Molecular Cell 2013, Blood 2015, Cell Reports 2015; Cancer Cell 2016; Nature (2018); Stem Cell Reports (2018) and Molecular Cell (2018 in press).

With recent acquisition of funds from NIH and NCI, we have multiple positions available for
1) Postdoctoral associates focused on experimental biology
2) Bioinformatics associate focused on computation analysis of genomics dataset
These positions will be relatively long-term and supported by our recently secured 5-year funds from NIH/NCI, American Cancer Society and Leukemia & Lymphoma Society.

The on-going projects include (1) biochemical characterization of epigenetic factors/complexes that regulate gene expression in stem cells or cancer cells; (2) CRISPR/dCas9-based editing and screening of pathways crucial for cancer development; (3) knockout and knock-in mouse models with deficiency in histone /DNA methylation regulation in context of development and tumorigenesis, with a special focus on hematopoietic disease; (4) epigenomic and transcriptome analyses (ChIP-Seq and RNA-Seq) of normal versus cancer cells to understand 3D chromatin structure and to delineate pathways essential for tumor growth.

Applicants should be self-motivated with a track record of publication in the above area, have laboratory and analytical skills, and be a critical thinker. Application shall include CV, a cover letter (with summary of research experiences and future interests, and expected availability date), reprints of publications, and contact information of three references. These should be sent to gregwang.unc@gmail.com

The starting annual salary for this postdoc position is around $48,000 in addition to covered medical insurance.