A Postdoctoral Fellow Position in Molecular Biology at Mayo Clinic (Rochester, MN, USA)

A postdoctoral research fellow position is available at the Mayo Medical School – Mayo Clinic (Rochester, Minnesota) to study the functions and mechanisms of post-transcriptional regulations in innate immune responses.

Mayo Clinic is widely regarded as one of the United States' greatest hospitals and ranked No. 1 in the country on the 2016–2017 U.S. News & World Report List of "Best Hospitals" of the United States, maintaining a position near the top for more than 25 years.

The potential candidate will utilize primary cell culture systems and mouse models in combination with high throughput RNA sequencing, ribosome-profiling, CLIP-seq to study post-transcriptional regulations (mRNA translation, mRNA decay) in inflammatory responses.

Highly motivated individuals with a recent Ph.D. and a background in immunology are encouraged to apply. Evidence of scientific publications is required and previous experience with molecular and cell biology and bioinformatics skills are desirable.

The salary is in accordance with the NIH standard. The start time is flexible in 2018.

Please send a CV including the contact information for at least two references to Dr. Wenqian Hu (whu.lab.mayo@gmail.com)

Selective Publications

Zhang, X., Chen, X., Liu, Q., Zhang, S., and Hu, W. * (2017) Translation repression via modulation of the cytoplasmic poly(A) binding protein in the inflammatory response. eLife 6: e27786. doi: 10.7554/eLife.27786 (*correspondence author)

Alvarez-Dominguez, J.R., Zhang, X., and Hu, W.* (2017) Widespread and dynamic translational control of red blood cell development. Blood 129:619-629 (*correspondence author)

Hu, W. *, Yuan, B., and Lodish, H.F. (2014) Cpeb4-mediated translational regulatory circuitry controls erythroid terminal differentiation. Developmental Cell 30(6):660-672 (*correspondence author)

Alvarez-Dominguez, J.R., Hu, W.*, Yuan, B., Shi, J., Park, S.S., Gromatzky, A.A., van Oudenaarden, A. and Lodish, H.F.* (2014) Multiple types of long non-coding RNAs regulate red blood cell development. Blood 123:570-581 (* correspondence authors)

Hu, W., Yuan, B., Flygare, J. and Lodish, H.F. (2011) Long non-coding RNA mediated anti-apoptotic activity in murine erythroid terminal differentiation. Genes & Development 25:2559-2572

Hu, W., Petzold, C., Baker, K., and Coller, J. (2010) Nonsense-mediated mRNA decapping occurs on polyribosomes in Saccharomyces cerevisiae. Nature Structural & Molecular Biology 17:244-247

Hu, W., Sweet, T., Chamnongpol, S., Baker, K., and Coller, J. (2009) Co-translational mRNA decay in Saccharomyces cerevisiae. Nature 461:225-229