Postdoctoral Research Fellowships in Centrosome/cilia biology and high-throughput biology of cells and tissue.

Postdoctoral Fellowships are available in the Pelletier lab at the Lunenfeld-Tanenbaum Research Institute in Mount Sinai Hospital in Toronto, Canada. Our lab is interested in the molecular mechanisms that govern centrosome-related processes in human cells including centriole duplication, pericentriolar material assembly, ciliogenesis, cell motility and mitotic spindle formation. Our studies revolve around cutting-edge quantitative imaging approaches (from low- to super-resolution), high-content screening with emphasis on advanced morphometric measurements ranging from single cells to developing tissues/organoids. We remain keenly interested in the use of functional proteomics to systematically elucidate protein-protein interactions that are essential to maintain proper centrosome and cilia function during animal development. As such, we are especially interested in linking functional proteomics studies, genome-scale RNAi and CRISPR/Cas9 screens to understand, at the molecula!
r level, how centrosome-cilia related processes can go awry in cancer and other clinically relevant disorders like microcephaly and myriad ciliopathies and how their function ensures normal tissue homeostasis.

In this position, the successful applicants will be part of a vibrant, fast-paced, dynamic and multi-disciplinary environment with outstanding research infrastructure/support and will play an integral role in novel and ongoing projects within the laboratory. Applicants with experience in any of the following disciplines are preferred: single cell analytics and statistical approaches to quantitative microscopy; advanced cellular imaging modalities; proteomics and functional genomics. Outstanding applicants in the broader field of molecular and cellular biology will also be considered.

Candidates interested in this position should forward their Cover Letter, CV, and name/contact information of 3 referees to pelletier@lunenfled.ca.

Selected Publications:

1. Prosser, S.L., and Pelletier, L. (2017). Mitotic spindle assembly in animal cells: a fine balancing act. Nat Rev Mol Cell Biol 18, 187-201.
2. St-Denis, N., Gupta, G.D., Lin, Z.Y., Gonzalez-Badillo, B., Veri, A.O., Knight, J.D., Rajendran, D., Couzens, A.L., Currie, K.W., Tkach, J.M., et al. (2016). Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. Cell Rep 17, 2488-2501.
3. Yeh, C., Coyaud, E., Bashkurov, M., van der Lelij, P., Cheung, S.W., Peters, J.M., Raught, B., and Pelletier, L. (2015). The Deubiquitinase USP37 Regulates Chromosome Cohesion and Mitotic Progression. Curr Biol 25, 2290-2299.
4. Gupta, G.D., Coyaud, E., Goncalves, J., Mojarad, B.A., Liu, Y., Wu, Q., Gheiratmand, L., Comartin, D., Tkach, J.M., Cheung, S.W., et al. (2015). A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. Cell 163, 1484-1499.
5. Mennella, V., Agard, D.A., Huang, B., and Pelletier, L. (2014). Amorphous no more: subdiffraction view of the pericentriolar material architecture. Trends Cell Biol 24, 188-197.
6. Lawo, S., Hasegan, M., Gupta, G.D., and Pelletier, L. (2012). Subdiffraction imaging of centrosomes reveals higher-order organizational features of pericentriolar material. Nat Cell Biol 14, 1148-1158.

For more information visit:

http://pelletierlab.org/openpositions/