The Kumar Laboratory at Cedars-Sinai Medical Center, Regenerative Medicine Institute is looking for a passionate, inquisitive, and enthusiastic individual who wishes to investigate the cellular and molecular underpinnings of the kidney Stem/Progenitor cells and regenerative responses post -mammalian acute kidney injury with a goal to identify novel therapeutic targets and strategies to augment intrinsic regenerative responses and inhibit fibrosis post-injury. Such approaches will “kick-start” the acutely injured kidneys and prevent its progression to chronic kidney disease.

Coupling state-of-the-art transgenic mice to the repair/regeneration model of acute kidney injury the incumbent will study the key biological processes involved in the regeneration of an injured epithelia per se. To gain further insights into such regenerative responses, such responses are also interrogated during kidney development. In addition, the laboratory will leverage on the world-class human induced Pluripotent Stem Cell (iPS) core facilities of RMI to establish in-vitro human nephrogenesis systems for kidney disease modeling and investigation of human renal repair responses.

The incumbent will assigned to a four year funded project investigating the above processes, and will gain critical insights into kidney stem/progenitor cells and kidney repair/regeneration. In order to conduct this research the incumbent should have a primary interest in regenerative medicine and stem cells, molecular cloning, next generation sequencing such as RNA-seq and Chip-Seq, high resolution imaging, and Crispr/Cas9-based gene editing methodologies.

The ideal candidate will have outstanding molecular and cell biology training with experience of the above genetic technologies.

The recently published paper illustrates the type of scientific work the laboratory conducts:
Sox9 Activation Highlights a Cellular Pathway of Renal Repair in the Acutely Injured Mammalian Kidney. Kumar S et al. Cell Reports 2015 August 25, 12: 1325 - 38.

If interested to pursue kidney Stem/Progenitor cell work coupled with mice and human repair/regeneration utilizing cutting-edge genetics, please do not hesitate to contact me for further information:

Dr Sanjeev Kumar, MD,MRCP(UK), Ph.D
John Merrill Transplant Scholar of American Society of Nephrology
Assistant Professor, Biomedical Sciences/Regenerative Medicine
Visiting Assistant Professor, David Geffen School of Medicine, UCLA
127 S San Vicente Blvd
Suite A8401, Regenerative Medicine Institute,
Advanced Health Sciences Pavilion
Cedars Sinai Medical Center
Los Angeles, 90048
Tel No: +14243152316/ Cell: 8572648005