"Multiple" postdoctoral positions in the Department of Neuroscience
Mayo Clinic College of Medicine, FLORIDA

MAYO CLINIC DEPARTMENT OF NEUROSCIENCE is internationally recognized for academic excellence in the neurodegenerative disorders. Scientists within the neuroscience department have strong expertise in neurogenetics, neuropathology, animal disease modeling, neuroinflammation, and experimental therapeutics. The Department hosts the NIH-designated Alzheimer’s Disease Research Center and the Udall Center of Excellence for Parkinson’s Disease Research.

Kim lab introduction
The broad interest of Kim lab is to understand the pathogenic mechanisms of Alzheimer’s disease and other related neurodegenerative diseases and to identify novel therapetuic targets. Current research efforts aim to understand the roles of Apolipoprotein (ApoE) and ApoE-regulating proteins, such as ABCA1 and LDLR, in Alzheimer’s disease. We are also interested in studying the role of microRNAs and lncRNAs in Alzheimer’s disease, other neurodegenerative diseases, brain aging, obesity, and cardiovascular diseases.
Our recent articles related with the current projects
1) J Neurosci. 2015 Nov 4;35(44):14717-26. doi: 10.1523/JNEUROSCI.2053-15.2015.
microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain.
http://www.ncbi.nlm.nih.gov/pubmed/26538644
2) Sci Transl Med. 2015 Nov 18;7(314):314ra184. doi: 10.1126/scitranslmed.aad1904.
The E3 ubiquitin ligase Idol controls brain LDL receptor expression, ApoE clearance, and Aβ
amyloidosis.
http://www.ncbi.nlm.nih.gov/pubmed/26582899

Candidate’s qualifications
- Candidates are expected to have expertise in transgenic or knockdown/knockout approach in mouse models.
- Strong background in molecular and cell biology techniques is preferred, but not required.
- Candidates must be highly motivated and have the ability to design and conduct experiments with minimal guidance or fully independently.
- Exceptional candidates will have ample opportunity to embark on new projects based on his/her own prior expertise.

Salary, Benefits, & Career development
- All postdoctoral positions will be supported up to 5 years by multiple NIH R01 grants.
- Candidates will have career development opportunities, such as applying for postdoctoral fellowships and attending international conferences.
- Fringe benefits including health and dental insurance are available for spouse and children.
- Because the cost of living in Jacksonville, Florida, is much lower than most other big cities, salary will be very competitive. Salary will be still matched to the NIH NRSA stipend scale.

Application process
- Please email the following items in "one" PDF file to kim.jungsu@mayo.edu
1. Cover letter, including brief statement of achievements and future research interest
2. CV, including detail technical expertise and PubMed links for the published articles
3. Contact information of at least three references
- Please use “Job application – Your Name” in the subject/title of email.

Jungsu Kim, Ph.D.
Senior Associate Consultant
Assistant Professor
Department of Neuroscience
Mayo Clinic College of Medicine
4500 San Pablo Road
Jacksonville, FL 32224

PS) If preferred, onsite interview is available during the following conferences.
http://www.icmn2016.org May 9 – 11, Seoul, Korea
http://www.keystonesymposia.org/index.cfm?e=web.meeting.program&meetingid=1423 June 12 – 16, Colorado
https://www.alz.org/aaic/program/overview.asp July 24 – 28, Toronto, Canada
https://www.sfn.org/annual-meeting/neuroscience-2016 Nov. 12 – 16, San Diego

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Department of Genetics & Complex Diseases and Immunology & Infectious Diseases at Harvard T.H. Chan School of Public Health でのポスドク募集について。

私の所属するHarvard T.H. Chan School of Public Health のHorngラボで博士研究員を募集していますのでお知らせいたします。Prof. Horng は若手の非常に優秀な免疫学者であり多くの業績を出されています。特にマクロファージ研究の第一人者でありInflammasome研究を行っているとともに現在はマクロファージにおけるbioenergeticsについて精力的に研究を行っています。最近ではImmunometabolismのKeystone Symposiaにおいて座長もされています。研究内容の詳細は以下の通りですのでご確認ください。
Department のレベルは非常に高く、横のつながりが強いため研究の幅も広がり非常にやりやすい環境かと思います。ラボ自体は少人数でボスと密にコミュニケーションを取っています。過去に数人、日本人も所属しており、ボスは日本人への理解があります。
ご興味がある方は以下の内容をご確認の上、直接Prof. Horngへご連絡ください。
日本語でのご質問もわたくしの方で受け付けております。　mshibata@hsph.harvard.edu
柴田宗彦

Our lab in the Department of Genetics & Complex Diseases and Immunology & Infectious Diseases at Harvard T.H. Chan School of Public Health is looking for an outstanding postdoctoral fellow. Emerging studies indicate that metabolic reprogramming critically controls macrophage activation, and a variety of projects are available in the lab addressing various aspects of such control, including the metabolic basis of Nlrp3 inflammasome activation; metabolic crosstalk between tumor associated macrophages and tumor cells; and metabolic influences on chromatin-mediated control of macrophage activation and memory.

Candidates should be skilled in cell biology, molecular biology, and basic mouse work. Preference will be given to candidates with experience in studying macrophage biology, particularly metabolism, signaling, and/or gene regulation, as demonstrated in their publication record. Candidates must have a Ph.D. or Ph.D./M.D. degree.

Please submit application, including a cover letter, CV and names and contact information of at least 3 references to:

Tiffany Horng, Ph.D.
Associate Professor
Department of Genetics and Complex Diseases
Harvard School of Public Health
655 Huntington Ave, II-115
Boston, MA 02115
thorng@hsph.harvard.edu

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The Dasgupta lab is looking for a highly motivated, self-driven and ambitious postdoctoral researcher to start around September, 2016 in the Division of Oncology at Cincinnati Children’s Hospital Medical Center. The ideal candidate could be finishing up graduate studies or completed graduate studies with no more than one year of post-PhD research experience. Experience in molecular biology including in-depth understanding of molecular cloning, DNA, RNA and protein work and extensive cell culture is required. Some experience in mouse genetics is preferable. Background in cancer biochemistry, metabolism, signaling and genetics will be considered favorably and interest in the above fields is necessary. Candidates with an interest in the position should send their CV and contact information for 3 references to: Biplab.DasGupta@cchmc.org.
Using genetically engineered mouse models and human tissue, the Dasgupta lab has been engaged in cutting-edge research to understand neural stem cell metabolism, genetic and metabolic uniqueness of glioblastoma (a type of brain tumor) subtypes, energy and nutrient sensing signaling pathways in cancer versus normal cellular counterparts and the built-in metabolic vulnerabilities of human cancer cells. We are also deeply interested to understand the mechanisms by which non-genetic factors regulate the incidence and penetrance of human cancer. We have published our work in highly visible journals including Nature Communications, PNAS, Cancer Cell, and Cancer Research. Our current study on a novel mechanism of tumorigenesis in pediatric brain tumors will be published soon in Neuro-Oncology, and studies on the bioenergetic regulation of brain tumors is under review in Nature Medicine. Click on the PubMed link to learn more.
http://www.ncbi.nlm.nih.gov/sites/myncbi/biplab.dasgupta.1/bibliography/43932883/public/?sort=date&direction=ascending

Biplab Dasgupta, PhD, MS
Associate Professor
UC Department of Pediatrics
Division of Oncology
Cincinnati Children’s Hospital Medical Center

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私の友人であるphysician-scientistのDr. Edward W. Wangが今年の8月からロサンゼルスにあるCity of Hopeで新たに研究室を立ち上げることになりました。そこで、彼の研究室でポスドクを1名募集することになったそうです。彼はとても人柄がよく、優しく、マメな方です。研究熱心で、研究の話をすると本当にサイエンスが好きなんだなということがわかります。また、日本人とも一緒に研究した経験を持っているので、日本人の性格をよく理解しているため、初めて海外で働く方にとっては働きやすいと思います。

彼の研究はがん細胞におけるTRAIL耐性についてです。もともとはDNAダメージに関する研究をしており、そこでp53をターゲットとしたsmall moleculesを検索していたそうですが、その際にdeath receptor (DR5) を多く誘導するsmall moleculesを見つけたそうです。このタンパクがTRAIL耐性を回復させる働きを持っているそうです。それを元に、将来的に臨床試験をすることを目的として、まずはトランスレーショナル研究としてメカニズムの解明に取り組んでいます。

彼の研究に興味があり、もしアメリカで研究することに興味を持っている方がいましたら、お気軽に彼に連絡を取ってください（edw.coh@gmail.com）。募集条件は卒業したてのPhDを有した研究者となっています。詳しい募集要項は以下の記載を参照してください。
彼の研究に関する詳細は私に聞かれても難しいですが、彼の人柄についてや、アメリカで研究することに関して何か質問がある方がいらっしゃいましたら、お気兼ねなく私に連絡してください（hfuruy@hawaii.edu）。

以下に彼の募集に関する原文を載せます。（引用元：http://chm.tbe.taleo.net/chm04/ats/careers/requisition.jsp?org=CITYOFHOPE&cws=1&rid=7388）

Requisition ID: 7388

Job Title: Postdoctoral Fellow - Wang lab

Position Summary and Key Responsibilities:

A newly funded lab at the department of medical oncology of City of Hope, Los Angeles, is looking for a talented postdoctoral fellow for translational research targeting the extrinsic and intrinsic apoptotic pathways of cancer cells. Ongoing studies are focusing on death receptor-mediated cancer cell death and reversal of tumor resistance to TNF-related apoptosis-inducing ligand (TRAIL) or death receptor agonistic antibodies by small molecules. Qualified candidate should have a recent PhD with research experiences in apoptosis, autophagy, lysosomal degradation, or DNA damage/repair of tumor cells. Skills of tissue culture, molecular cloning, gene expression and knockout, protein purification/identification, flow cytometry, mouse tumor xenograft models are preferred. Excellent written and interpersonal communication skills are required. Bioinformatics skills are a plus.

Full application including a statement of research motivation/experiences/interests, updated CV with a list of publication, and at least 3 references with contact information should be submitted by email to Edward W. Wang at edw.coh@gmail.com. The position is funded for 1 year and renewable upon satisfactory evaluation.

Minimum Requirement:

Recent PhD or equivalent in biomedical sciences
Excellent verbal and written communication skills.

研究者の連絡先：
Edward W. Wang, MD, PhD
Assistant professor
Department of Medical Oncology
City of Hope Comprehensive Cancer Center
1500 E Duarte Road
Duarte, CA 91010
edw.coh@gmail.com

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A postdoctoral position is immediately available in the department of Gastrointestinal Medical Oncology to conduct research in cancer biology of colorectal tumorigenesis. This position will be responsible for conducting studies on novel genetic mouse model developed in our laboratory to study lipid signaling role in colonic tumorigenesis. Projects will include also the use of colon cancer cell culture models for in depth mechanistic studies of lipid signaling interaction with Wnt/B-catenin signaling.

The duties of this position include:
1. To conduct study design, experimentation, data collection, and data analysis.
2. To conduct experimental assays and perform data analysis to characterize novel genetic mouse models in regard to lipid and Wnt/catenin signaling.
3. To prepare manuscript and present data at national annual meetings.

Qualifications:
To be considered for this position you must have a Ph.D or equivalent doctorate degree.

Interested applicants should email a CV and research letter of interest to ishureiqi@mdanderson.org

Contact:
Imad Shureiqi, M.D., M.S.
Department of Gastrointestinal Medical Oncology
University of Texas MD Anderson Cancer Center

Institution Web Site: http://www.mdanderson.org

MD Anderson is the number one cancer center in cancer care in the United States by the U.S.News and World Report’s “America’s Best Hospitals” survey. It ranks 1st in the number of awarded grants from National Cancer Institute. It offers active graduate and postdoctoral training programs and the unmatched scientific environment of the Texas Medical Center, the world's largest biomedical center. MD Anderson is an equal opportunity/affirmative action employer. Houston is the 4th largest city in the United States with relatively low living cost and no state or city income tax.

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【研究室の概要】ホームページ（http://www.med.nagoya-u.ac.jp/hygiene/）にありますように、本教室は、分子腫瘍学（メラノーマ等の皮膚癌）または分子神経学（聴覚等）の分子生物学領域の研究と環境科学の両面から環境医学研究を推進している研究室です。2016年5月現在、9～10名の教員と博士研究員（ポスドク）が在籍しています。これらのメンバーが少しずつ入れ代わりながら教室の研究を推進しております。
【募集内容】分子生物学領域（特に、分子腫瘍学または分子神経学）の御経験がある方を対象として若干名の特任助教または博士取得後研究員を募集致します。
【提出書類と選考方法】1）履歴書、2）志望動機、3）研究業績（論文・特許・科学研究費等外部資金取得状況）、4）現在迄の研究概要と簡単な抱負（A4で1枚以内）、5）現在の指導者および学位論文指導者の連絡先（emailアドレスと電話番号）についてPDFの添付文書にて、電子メール（katomasa@med.nagoya-u.ac.jp）にてお送りください。書類を拝見させていただきました後、1～2回の面接をさせていただき、面接後に最終的な採否に関する御連絡をメールでさせていただく予定です。尚、海外在住の方は、スカイプで面接させていただくことも可能です。
【研究内容】主として環境因子（紫外線・騒音・重金属等）が、①皮膚機能や皮膚腫瘍（メラノーマや扁平上皮癌等）または②神経（小脳や聴覚）に与える影響を調べる研究を遂行します。尚、研究内容の詳細は、候補者と建設的に話し合いをして、双方が納得した形で決めるようにする等、柔軟性を持たせたいと考えております。
【応募資格】医歯薬学系・理学・農学系・環境科学系博士号保持または来春取得見込みの方。
【任期】任期あり（3月末までの単年の契約更新ですが、両者の合意に基づき延長可能です）。
【給与】名古屋大学の規定に準じます。　　
【書類の締め切り】平成28年7月31日（適任者が見つかった場合は、締め切り日前に公募を打ち切らせていただくことがあります）
【採用開始日】平成28年10月頃～平成29年4月末日の間（応相談）
【最近の主たる業績】
01) Oncotarget 7(3):2379-90, 2016.
02) Oncotarget 6(16):14290-9, 2015.

03) Nature Immunology 15:758-66, 2014.
04) Proc Natl Acad Sci USA 110(32):13085-90, Aug, 2013.
05) Neurobiol Aging 33(3):626.e25-34, 2012.
06) Cancer Res 71(22):6997-7009, 2011.
07) Cancer Res 71(16):5393-9, 2011.
08) Proc Natl Acad Sci USA 108(41):17111-6, 2011.
09) J Biol Chem 286(34):29621-6, 2011.
10) PLoS Biol 9(9): e1001162, 2011.
11) Proc Natl Acad Sci USA 107(29):13051-6, 2010.
12) J Clin Invest 120(6):2030-9, 2010.
13) J Exp Med 207(3):491-503, 2010.
14) Cancer Res 70(1):24-9, 2010.
15) J Clin Invest 119(5):1251-63, 2009.
【連絡先】 加藤昌志（E-mail: katomasa@med.nagoya-u.ac.jp）

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