POSTDOCTORAL POSITION IN DNA REPLICATION
A postdoctoral position is open in our laboratory at the Institute of Human Genetics, CNRS, Montpellier, France.

Place of work
The Institute of Human Genetics (www.igh.cnrs.fr) is a modern large CNRS Institute located in the University and Hospital area in Montpellier. Fully endowed with state-of-the-art scientific equipment, the IGH generates a stimulating and international research environment, for high-quality and intensive scientific life. The working language is English. The city is one of the most lively and concentrated areas for research scientists in France.

The team
Our multinational team wishes to understand how DNA replication origins are recognized, and how their organization is coordinated with the cell fate. Our model systems include cell cultures from both mouse and human cells, as well as in-vitro DNA replication systems from Xenopus eggs. Recently, our laboratory unravelled how genetic and epigenetic features shape DNA replication origin recognition and organization. The project is focused on functional aspects of metazoan DNA replication origins, using in-vivo cell systems as well as in-vitro cell systems to analyse the regulation of DNA replication and its associated factors.

Some Recent publications
• Fragkos, M., Ganier, O., Coulombe, P. and Méchali, M. (2015) DNA replication origin activation in space and time. Nature Rev. Mol. Cell Biol. 16, 360-374.
• Cayrou C, Ballester B, Peiffer I, Fenouil R, Coulombe P, Andrau JC, van Helden J, Méchali M. (2015), The chromatin environment shapes DNA replication origin organization and defines origin classes. Genome Res., 12, 1873-1885.
• Traver, S., Coulombe, P., Kitzmann, M., Peiffer, I., Hutchins, J., Latreille, D., and Méchali, M. (2014) MCM9 is Required for Mammalian DNA Mismatch Repair. Mol. Cell, 59, 831-839.
• Coulombe, P., Grégoire, D., Tsanov, N., and Méchali, M. (2013) A spontaneous Cdt1 mutation in 129 mouse strains reveals a regulatory domain restraining replication licensing. Nature Com. 4, 1-10.
• Lutzmann, M., Grey, C., Traver, S., Ganier, O., Maya-Mendoza, A., Ranisavljevic, N., Bernex, F., Nishiyama, A., Montel, N., Gavois, E., Forichon, L., de Massy, B., and Méchali, M. (2012) MCM8- and MCM9-Deficient Mice Reveal Gametogenesis Defects and Genome Instability Due to Impaired Homologous Recombination. Mol Cell. 47, 523-534.

Qualification
We would be glad to receive applications from highly motivated scientists, able to work independently, with a solid background in nuclear metabolism and strong expertise in molecular biology. The position is for at least two years.

Please submit a curriculum vitae and contact information of two referees to Marcel Méchali, Institute of Human Genetics, CNRS, 141 rue de la Cardonille, 34396 Montpellier, France. Tel: +33 (0) 434 359 917; e-mail: mechali@igh.cnrs.fr; website: www.igh.cnrs.fr./equip/mechali/