Skinの再生医療・免疫学のポスドク募集（米国ペンシルバニア大学）

Thomas LeungはDavid BaltimoreラボでPh.D.をとり、スタンフォード大学でポスドクを終えた新進気鋭の免疫学者・再生医療研究者・Dermatologistで、ペンシルバニア大学で研究室を立ち上げました。性格は明朗快活、頭脳は明晰、人格的にも優れた人物で、日本や日本文化にも好意的です。

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The laboratory of Thomas Leung at the University of Pennsylvania (www.thomasleunglab.org) is inviting applications for a postdoctoral researcher.

Our group studies how injured tissues heal, and in some cases, how injured tissues regenerate without a scar. We have innovated new methods for studying these processes in mice and humans, and discovered cellular, molecular, and genetic mechanisms governing inflammation, wound healing, and tissue regeneration. Based on our findings, we have several active clinical trials testing our conclusions in the clinic. As a practicing dermatologist, I try to use clinical observations to drive basic science discovery. An overarching goal of our work is to identify novel therapeutic strategies to improve healing (with or without scars) in humans.

We are seeking a qualified postdoctoral fellow with an interest in stem cells, inflammation, tissue regeneration, and regenerative medicine. The fellow will design and perform experiments using a variety of model systems (mouse, tissue culture, 3D human tissue culture) and techniques (molecular, biochemistry, genetic, histology, and genomics). An MD and/or PhD in a science-related field, excellent written and verbal communication skills, and the ability to work interactively are required.

Postdoctoral research in the lab commonly involves close interactions both within the lab and with collaborating groups at the University of Pennsylvania. Postdoctoral training includes participation in seminars and retreats of the Department of Dermatology and Institute of Regenerative Medicine. A major goal of our lab is to mentor and train fellows for future careers in academics and industry.
To apply, please email a letter of interest and a CV that includes three references to Dr. Leung (thl@upenn.edu). Please include a statement about your interest in our lab and your career goals and objectives.

Publications
Leung T.H., Snyder E.R., Liu Y., Wang J., and Kim S.K. (2015)
A cellular, molecular and pharmacological basis for appendage regeneration in mice.
Genes and Development. 29(20):2097-107. PMID: 26494786.
- Research Highlight: How mice regrow ear tissue. Nature 527: 136-137.
Gorrell E.S., Leung T.H., Khuu P., and Lane A.T. (2015)
Purified Type I Collagen Wound Matrix Improves Chronic Wound Healing in Patients with Recessive Dystrophic Epidermolysis Bullosa.
Pediatric Dermatology. 32(2):220-5. PMID: 25557742.
Sebastiano V., Zhen H.H., Derafshi B.H., Bashkirova E., Melo S., Wang P., Leung T.L., Siprashvili Z., Tichy A., Li J., Ameen M., Hawkins J., Lee S., Li L., Schwertschkow A., Bauer G., Lisowski L., Kay M.A., Kim S.K., Lane A.T., Wernig M., and Oro A.E. (2014)
Human COL7A1-corrected induced pluripotent stem cells for the treatment of recessive dystrophic
epidermolysis bullosa.
Science Translational Medicine. 26;6(264):264ra163. PMID: 25429056.
Danial C., Tichy A.L., Tariq U., Swetman G.L., Khuu P., Leung T.H., Benjamin L., Teng J., Vasanawala S.S., and Lane A.T. (2014)
An open-label study to evaluate sildenafil for the treatment of lymphatic malformations.
Journal of the American Academy of Dermatology. S0190-9622(14)01119-0. PMID: 24656411. [pdf]
Leung T.H., Zhang L., Wang J., Ning S., Knox S., and Kim S.K. (2013)
Hypochlorite ameliorates NF-κB-mediated skin diseases.
The Journal of Clinical Investigation. 123(12):5361-70. PMID: 24231355.
- Covered by BBC news, Huffington Post, The Scientist, Reader's Digest, Allure, Daily Mail, Telegraph
Covert M.W.*, Leung T.H.*, Gaston J.E. and Baltimore D. (2005)
Achieving Stability of LPS-Induced NF-κB Activation.
Science. 309(5742): 1854-7. PMID: 16166516.
* These authors contributed equally to this work.
Leung T.H., Hoffmann A., and Baltimore D. (2004)
One nucleotide change in a kappa B site can determine cofactor specificity for NF-κB dimers.
Cell. 118(4): 453-64. PMID: 15315758.
- Preview Article: Little things that count in transcriptional regulation. Cell. 118:406-408
Hoffmann A., Leung T.H., and Baltimore D. (2003)
Genetic analysis of NF-kappaB/Rel transcription factors defines functional specificities.
EMBO Journal. 22(20): 5530-9. PMID: 14532125.