Shinya Yamamoto's laboratory in the Department of Molecular and Human Genetics and the Jan and Dan Duncan Research Institute (NRI) at Baylor College of Medicine (BCM) is actively recruiting highly motivated and hard-working postdoctoral fellows.

The Yamamoto lab (http://goo.gl/OayxUp) uses the fruit fly Drosophila melanogaster to study the function of genes that are linked to neurological and neuropsychiatric disorders in human. We integrate state-of-the-art human genomics and Drosophila genetics tools & techniques to perform detailed in vivo functional studies of genes and variants that are associated with pediatric neurological diseases such as Autism and Intellectual Disability, as well as adult-onset disorders such as Alzheimer’s disease. The lab is also engaged in active collaborations with clinicians and clinical researchers in human genetics at BCM and around the country by functioning as one of the Model Organisms Screening Centers for the Undiagnosed Diseases Network (UDN, http://undiagnosed.hms.harvard.edu/). We also use mammalian model systems (e.g. cell lines, cultured neurons, mouse) to translate our basic findings from flies to human. The lab is part of the NRI (http://www.nri.texaschildrens.org!
/) and is immersed in a highly collaborative and stimulating environment.

【Selected Publications】
Yamamoto et al., "A mutation in EGF repeat-8 of Notch discriminates between Serrate/Jagged and Delta family ligands." 2012 Science

Yamamoto et al., "A Drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases." 2014 Cell

Bellen & Yamamoto, "Morgan’s legacy: fruit flies and the functional annotation of conserved genes." 2015 Cell

To apply for a postdoctoral position, previous experiences with Drosophila genetics is preferred but not required. One must have basic training in molecular biology (e.g. molecular cloning) and biochemistry (e.g. western blotting). Experiences with mammalian cell/neuronal culture work and/or biogenic amine (e.g. dopamine, serotonin) research will be considered a plus. Candidates must be able to work independently to develop their own research project, but also be willing to work as part of a larger group and be a great team player.

If you are interested in working with us, please send your Curriculum Vitae, 1-2 page document that describes your research interests and future goals, and contact information for three(3) references to yamamoto@bcm.edu. The position will remain open until filled.