POSTDOCTORAL POSITION IN DNA REPLICATION
A postdoctoral position is open in our laboratory at the Institute of Human Genetics, CNRS, Montpellier, France.

Place of work
The Institute of Human Genetics (www.igh.cnrs.fr) is a modern large CNRS Institute located in the University and Hospital area in Montpellier. Fully endowed with state-of-the-art scientific equipment, the IGH generates a stimulating and international research environment, for high-quality and intensive scientific life. The working language is English. The city is one of the most lively and concentrated areas for research scientists in France.

The team
Our multinational team wishes to understand how DNA replication origins are recognized, and how their organization is coordinated with the cell fate. Our model systems include cell cultures from both mouse and human cells, as well as in-vitro DNA replication systems from Xenopus eggs. Recently, our laboratory unravelled how genetic and epigenetic features shape DNA replication origin recognition and organization. The project is focused on functional aspects of metazoan DNA replication origins, using in-vivo cell systems as well as in-vitro cell systems to analyse the regulation of DNA replication and its associated factors.

Some Recent publications
• Fragkos, M., Ganier, O., Coulombe, P. and Méchali, M. (2015) DNA replication origin activation in space and time. Nature Rev. Mol. Cell Biol. 16, 360-374.
• Cayrou C, Ballester B, Peiffer I, Fenouil R, Coulombe P, Andrau JC, van Helden J, Méchali M. (2015), The chromatin environment shapes DNA replication origin organization and defines origin classes. Genome Res., 12, 1873-1885.
• Traver, S., Coulombe, P., Kitzmann, M., Peiffer, I., Hutchins, J., Latreille, D., and Méchali, M. (2014) MCM9 is Required for Mammalian DNA Mismatch Repair. Mol. Cell, 59, 831-839.
• Coulombe, P., Grégoire, D., Tsanov, N., and Méchali, M. (2013) A spontaneous Cdt1 mutation in 129 mouse strains reveals a regulatory domain restraining replication licensing. Nature Com. 4, 1-10.
• Lutzmann, M., Grey, C., Traver, S., Ganier, O., Maya-Mendoza, A., Ranisavljevic, N., Bernex, F., Nishiyama, A., Montel, N., Gavois, E., Forichon, L., de Massy, B., and Méchali, M. (2012) MCM8- and MCM9-Deficient Mice Reveal Gametogenesis Defects and Genome Instability Due to Impaired Homologous Recombination. Mol Cell. 47, 523-534.

Qualification
We would be glad to receive applications from highly motivated scientists, able to work independently, with a solid background in nuclear metabolism and strong expertise in molecular biology. The position is for at least two years.

Please submit a curriculum vitae and contact information of two referees to Marcel Méchali, Institute of Human Genetics, CNRS, 141 rue de la Cardonille, 34396 Montpellier, France. Tel: +33 (0) 434 359 917; e-mail: mechali@igh.cnrs.fr; website: www.igh.cnrs.fr./equip/mechali/

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Postdoc Position at Yildirim Lab, Duke University
Eda Yildirim Laboratory (http://sites.duke.edu/yildirimlab/) at the Department of Cell Biology of the Duke University School of Medicine, Durham, North Carolina is looking for a creative, accomplished and highly motivated post-doctoral fellow who is interested in research involving long noncoding RNA mediated epigenetic mechanisms and the role of these processes in cancer.

Preferred Qualifications
• Ph.D. (or doctoral degree equivalent) in Biochemistry, Genetics, or Cell Biology with a track record of publication in peer-reviewed journals
• Expertise in stem cell biology, chromosome biology, epigenetics or genome instability
• Ability to perform molecular & cellular protocols utilizing hematopoietic cells (i.e. animal bone marrow transplantation models, FACS-, and virus-based assays) and mouse disease models
• Excellent oral and written communication skills
• Demonstrated ability to work independently and as part of a team

To apply, please e-mail a single PDF file that includes the following to Dr. Eda Yildirim (eda.yildirim@duke.edu)
• A cover letter that describes your research and career goals
• A curriculum vitae, including a publication list with a brief (2-3 sentence) description of your contributions to published work.
• Names and contact information for 3 references.

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A Post Doctoral Fellow position is available in the laboratory of Dr. Kavitha Sarma. The lab investigates gene regulation by non-coding RNAs by employing a combination of biochemistry, cell and molecular biological methods, and genome wide approaches. Candidates with research interests in chromatin biology, epigenetics, and long non- coding RNAs are encouraged to apply. A strong background in RNA/protein biochemistry or in genomic data analysis is a plus.

Candidates should have a PhD (or equivalent) degree or should be close to obtaining their doctoral degree. Interested individuals should apply by submitting a cover letter stating the reason for their interest in the position, a CV including a list of publications, and the names and contact information for at least 3 references to ksarma@wistar.org.

The Wistar Institute is an independent biomedical research institute founded in 1892 and is world renowned for its research in cancers and vaccine development. It is located in the University City area of Philadelphia, in the heart of the University of Pennsylvania Campus. Both the Wistar Institute and the University of Pennsylvania provide resources to conduct cutting edge collaborative research, outstanding intellectual environments and state-of-the-art facilities.

We offer an excellent benefits package.

For more information about The Wistar Institute visit our website at www.wistar.org.

The Wistar Institute is an equal opportunity/affirmative action employer. It is the policy of The Wistar Institute to provide equal employment opportunities to all individuals regardless of race, color, creed, religion, national origin, ancestry, sex, age, veteran status, disability, sexual orientation, gender identity, or on the basis of genetic information, or any other characteristic protected by federal, state, or local law, with respect to all terms and conditions of employment.

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A postdoctoral position is available working in the laboratory of Hiroki Taniguchi Ph.D., a research group leader at the Max Planck Florida Institute (MPFI). The lab’s focus is on understanding neural circuit development and function of inhibitory interneuron subtypes (see below). We are looking for highly motivated individuals who will enjoy the process to achieve a unique science and have a strong ambition to create trends of neural circuit research in the future.

The MPFI in Jupiter, Florida is the first institute established by Germany’s prestigious Max Planck Society outside of Europe. The research focus of the MPFI is structure and function of neural circuits, the complex synaptic networks of the brain. The MPFI has had a lot of exciting seminars presented by world-renowned researchers, and a close relationship with the Scripps Florida Institute and Florida Atlantic University on the same campus. To be able to feel “Max Planck spirits” in US is another advantage in our institute.

(Research Topics)
Cortical inhibitory interneurons have many subtypes, each of which has a unique role in various functions of neural circuits. Thus, elucidating mechanisms by which their diversity arises and functional role of subtypes in neural circuit operation is one of key missions in neuroscience. We have taken advantage of mouse genetics, molecular biology, virology, and imaging techniques to understand fate specification, neural circuit development, and a role in higher-order brain functions, of cortical interneuron subtypes. In this recruitment, we are interested in candidates who are eager to study one of these subjects.

(Location)
Max Planck Florida Institute, Jupiter, Florida, USA.
Jupiter is located in south Florida and surrounded by a lot of nature.
There are many good school districts within the area.
It is warm throughout the year. It must be good for family.

(Qualification)
Applicants must have or be expected to receive a Ph.D.
Experience in imaging with two-photon microscopy and/or in vivo analysis of brain functions is preferred but not necessary.

(Salary and benefits)
In accordance with MPFI regulations

(Start of employment)
As early as possible (negotiable)

(Application and required documents)
1. Complete CV including a publication list, experimental skills and contact information on 3 reference persons
2. Description of current and previous research summary (1-2 page)
3. Description of the reason why you apply and what you want to do (1-2 page)

A PDF should be sent to Hiroki Taniguchi, Ph.D. via e-mail.
Contact prior to application is welcome.

E-mail: taniguchimpfi@gmail.com
Tel: 1-561-972-9260

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テキサス州ダラスのUT Southwestern Medical Center, Department of Immunologyで私たちの研究に参加して頂けるポスドクの方を募集しています。私たちの研究室では新規アダプター分子BCAPのTLRシグナリングおよびインフラマソーム活性化における役割を研究しています。応募資格はPh.DまたはM.D.を有しているかたで、免疫学、分子生物学、生化学のバックグラウンドをもつかたが望ましいです。Fully fundedな待遇となります。当研究室ではUT Southwestern Medical Centerの卓越した研究設備と共同研究体制を利用することができます。
当研究室のホームページです。
http://www4.utsouthwestern.edu/pasarelab/Pasare_Lab/Home.html

ご興味をお持ちの方は1)CV、2)これまでの研究の概略と抱負、3)3人の推薦者の連絡先を下記までご送付ください。

Chandrashekhar Pasare, Ph.D
Chair, Immunology Graduate Program
Associate Professor
Department of Immunology
University of Texas Southwestern Medical Center
6000 Harry Hines Blvd, NA7.308
Dallas, TX 75390-9093
E-mail: chandrashekhar.pasare@utsouthwestern.edu

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Memorial Sloan-Kettering Cancer CenterのEmily Cheng 研究室では、現在Postdoctoral Fellow を数名募集しております。当研究室では、BCL-2ファミリーによるアポトーシス制御機構の解明、及びBCL-2ファミリーを標的とした新規癌治療法の確立を目指して研究をおこなっています。応募される方は、以下の英文広告をご参照の上、Dr. ChengまでCV及び推薦者3名の連絡リストをお送りください。なお、日本語でのご質問等ございましたら、当研究室出身の山内茜(akaneyamauchi@hotmail.com)までお気軽にお問合せ下さい。
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Postdoctoral positions are available for highly motivated individuals interested in studying the BCL-2 family and the fundamental mechanisms of cell death, the impact of cell death regulators in tumorigenesis and response to anticancer therapy, developing novel therapeutics targeting the BCL-2 family, and translating cell death mechanisms into targeted cancer therapy (Science 330: 1390-1393; Molecular Cell 36: 487-499; Nature Cell Biology 8:1348-1358; Science Signaling 6:ra20; Cancer Cell 25, 530–542; Nature Cell Biology 17:1270-1281). We are particularly interested in the pathogenesis and targeted therapy of lung cancer, mechanisms of resistance to targeted therapy, and how to overcome resistance to targeted therapy.

Applicants should hold a Ph.D. degree and have a strong background in molecular/cellular biology, biochemistry, mouse genetics, or cancer biology, and a good publication record.

Full applications including curriculum vitae and a list of three references should be submitted through chengpostdocapps@gmail.com to: Emily Cheng, M.D., Ph.D., Associate Member, Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA.

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Skinの再生医療・免疫学のポスドク募集（米国ペンシルバニア大学）

Thomas LeungはDavid BaltimoreラボでPh.D.をとり、スタンフォード大学でポスドクを終えた新進気鋭の免疫学者・再生医療研究者・Dermatologistで、ペンシルバニア大学で研究室を立ち上げました。性格は明朗快活、頭脳は明晰、人格的にも優れた人物で、日本や日本文化にも好意的です。

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The laboratory of Thomas Leung at the University of Pennsylvania (www.thomasleunglab.org) is inviting applications for a postdoctoral researcher.

Our group studies how injured tissues heal, and in some cases, how injured tissues regenerate without a scar. We have innovated new methods for studying these processes in mice and humans, and discovered cellular, molecular, and genetic mechanisms governing inflammation, wound healing, and tissue regeneration. Based on our findings, we have several active clinical trials testing our conclusions in the clinic. As a practicing dermatologist, I try to use clinical observations to drive basic science discovery. An overarching goal of our work is to identify novel therapeutic strategies to improve healing (with or without scars) in humans.

We are seeking a qualified postdoctoral fellow with an interest in stem cells, inflammation, tissue regeneration, and regenerative medicine. The fellow will design and perform experiments using a variety of model systems (mouse, tissue culture, 3D human tissue culture) and techniques (molecular, biochemistry, genetic, histology, and genomics). An MD and/or PhD in a science-related field, excellent written and verbal communication skills, and the ability to work interactively are required.

Postdoctoral research in the lab commonly involves close interactions both within the lab and with collaborating groups at the University of Pennsylvania. Postdoctoral training includes participation in seminars and retreats of the Department of Dermatology and Institute of Regenerative Medicine. A major goal of our lab is to mentor and train fellows for future careers in academics and industry.
To apply, please email a letter of interest and a CV that includes three references to Dr. Leung (thl@upenn.edu). Please include a statement about your interest in our lab and your career goals and objectives.

Publications
Leung T.H., Snyder E.R., Liu Y., Wang J., and Kim S.K. (2015)
A cellular, molecular and pharmacological basis for appendage regeneration in mice.
Genes and Development. 29(20):2097-107. PMID: 26494786.
- Research Highlight: How mice regrow ear tissue. Nature 527: 136-137.
Gorrell E.S., Leung T.H., Khuu P., and Lane A.T. (2015)
Purified Type I Collagen Wound Matrix Improves Chronic Wound Healing in Patients with Recessive Dystrophic Epidermolysis Bullosa.
Pediatric Dermatology. 32(2):220-5. PMID: 25557742.
Sebastiano V., Zhen H.H., Derafshi B.H., Bashkirova E., Melo S., Wang P., Leung T.L., Siprashvili Z., Tichy A., Li J., Ameen M., Hawkins J., Lee S., Li L., Schwertschkow A., Bauer G., Lisowski L., Kay M.A., Kim S.K., Lane A.T., Wernig M., and Oro A.E. (2014)
Human COL7A1-corrected induced pluripotent stem cells for the treatment of recessive dystrophic
epidermolysis bullosa.
Science Translational Medicine. 26;6(264):264ra163. PMID: 25429056.
Danial C., Tichy A.L., Tariq U., Swetman G.L., Khuu P., Leung T.H., Benjamin L., Teng J., Vasanawala S.S., and Lane A.T. (2014)
An open-label study to evaluate sildenafil for the treatment of lymphatic malformations.
Journal of the American Academy of Dermatology. S0190-9622(14)01119-0. PMID: 24656411. [pdf]
Leung T.H., Zhang L., Wang J., Ning S., Knox S., and Kim S.K. (2013)
Hypochlorite ameliorates NF-κB-mediated skin diseases.
The Journal of Clinical Investigation. 123(12):5361-70. PMID: 24231355.
- Covered by BBC news, Huffington Post, The Scientist, Reader's Digest, Allure, Daily Mail, Telegraph
Covert M.W.*, Leung T.H.*, Gaston J.E. and Baltimore D. (2005)
Achieving Stability of LPS-Induced NF-κB Activation.
Science. 309(5742): 1854-7. PMID: 16166516.
* These authors contributed equally to this work.
Leung T.H., Hoffmann A., and Baltimore D. (2004)
One nucleotide change in a kappa B site can determine cofactor specificity for NF-κB dimers.
Cell. 118(4): 453-64. PMID: 15315758.
- Preview Article: Little things that count in transcriptional regulation. Cell. 118:406-408
Hoffmann A., Leung T.H., and Baltimore D. (2003)
Genetic analysis of NF-kappaB/Rel transcription factors defines functional specificities.
EMBO Journal. 22(20): 5530-9. PMID: 14532125.

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A cellular and molecular biology laboratory in the Department of Medicine at Boston University School of Medicine is seeking to hire a post-doctoral research fellow. Boston University School of Medicine and Boston University are premier research institutes drawing substantial amount of extramural and industry funding. The Division of Nephrology is within the Department of Medicine, whose goal is to understand various aspects of renal diseases, their pathogenesis, effects on various organ systems and has been at the forefronts of developing novel pathogenic biomarker for glomerulonephritis and other vascular diseases.

One of the research focuses of the group is to characterize the pathogenesis of vascular disease in patients with chronic kidney disease. Successful candidate will conduct research at the intersection of cellular biology, biochemistry, and analytical chemistry. The candidate will work with a multidisciplinary team including clinical nephrologists, molecular and cellular biologists and proteomic experts and system biologists of Boston University and Boston University School of Medicine, thus the project is truly of translational in nature. The candidate should be a US citizen/permanent resident with a PhD in chemistry or physics, who wishes to broaden the horizon and obtain hands-on experience in human pathophysiology and work on project with high clinical impact.

US citizens or green card holders are preferred for this position. Self-motivation, dedication to work and enthusiasm to learn are must for this position and a person who can commit 2-5 years for a productive scientific career are encouraged to apply. The position is available on immediate basis.

Interested applicants should contact Dr Vipul Chitalia, MD PhD, Assistant Prof of Medicine, Boston University School of Medicine, Boston. vichital@bu.edu

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Shinya Yamamoto's laboratory in the Department of Molecular and Human Genetics and the Jan and Dan Duncan Research Institute (NRI) at Baylor College of Medicine (BCM) is actively recruiting highly motivated and hard-working postdoctoral fellows.

The Yamamoto lab (http://goo.gl/OayxUp) uses the fruit fly Drosophila melanogaster to study the function of genes that are linked to neurological and neuropsychiatric disorders in human. We integrate state-of-the-art human genomics and Drosophila genetics tools & techniques to perform detailed in vivo functional studies of genes and variants that are associated with pediatric neurological diseases such as Autism and Intellectual Disability, as well as adult-onset disorders such as Alzheimer’s disease. The lab is also engaged in active collaborations with clinicians and clinical researchers in human genetics at BCM and around the country by functioning as one of the Model Organisms Screening Centers for the Undiagnosed Diseases Network (UDN, http://undiagnosed.hms.harvard.edu/). We also use mammalian model systems (e.g. cell lines, cultured neurons, mouse) to translate our basic findings from flies to human. The lab is part of the NRI (http://www.nri.texaschildrens.org!
/) and is immersed in a highly collaborative and stimulating environment.

【Selected Publications】
Yamamoto et al., "A mutation in EGF repeat-8 of Notch discriminates between Serrate/Jagged and Delta family ligands." 2012 Science

Yamamoto et al., "A Drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases." 2014 Cell

Bellen & Yamamoto, "Morgan’s legacy: fruit flies and the functional annotation of conserved genes." 2015 Cell

To apply for a postdoctoral position, previous experiences with Drosophila genetics is preferred but not required. One must have basic training in molecular biology (e.g. molecular cloning) and biochemistry (e.g. western blotting). Experiences with mammalian cell/neuronal culture work and/or biogenic amine (e.g. dopamine, serotonin) research will be considered a plus. Candidates must be able to work independently to develop their own research project, but also be willing to work as part of a larger group and be a great team player.

If you are interested in working with us, please send your Curriculum Vitae, 1-2 page document that describes your research interests and future goals, and contact information for three(3) references to yamamoto@bcm.edu. The position will remain open until filled.

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