We are interested in a fundamental question in cell biology: how do our cells defend the integrity of our nuclear DNA? This is because DNA, the blueprint of life, is an active large molecule with many active chemical moieties that allow it to receive numerous modifications. Such modification will result in the change of the double helix structure, which then leads to abnormal or even lethal endpoint on the affected cell, for instance, the rising of cancer, premature aging and neuro-degenerative diseases.

Fortunately, it turns out that evolution has overlaid elegant signaling pathways to sense the presence and initiate the repair of DNA damage that can arise both through exposure to environmental stress (such as the UV light) and through cellular activities (such as free radical species). These signaling pathways are called DNA damage response.

We use pharmacological, biochemical, structural and genetic tools to understand molecular mechanisms underlying the DNA damage response, and translating that knowledge into therapeutic strategies against human cancers.

Please see our website for detail: http://pharmacology.case.edu/department/Faculty/Primary/Labs/Zhang/Default.aspx

Self-motivated individuals who have a PhD degree are encouraged to apply. Strong background in biochemistry (Western blotting, immunofluorescence, immunoprecipitation, etc), molecular (PCR, cloning and vector generation) and cellular (cell culture, transfection, and so on) biology is required.

Interested applicants should forward their CV and a list of three references through email to:

Dr. Youwei Zhang, Ph.D.

yxz169@case.edu

Department of Pharmacology, Case Comprehensive Cancer Center, Case Western Reserve University, in Cleveland, Ohio, USA.