Job Opportunity (Postdoctoral Fellow) in Dr. Nghiem's Laboratory (University of Washington Dermatology)

A position for a postdoctoral fellow is available in the laboratory of Dr. Paul Nghiem (Medicine/Dermatology, UW Medicine South Lake Union) to study UV-induced DNA damage responses, skin carcinogenesis, and small-molecule inhibitors of the ATR pathway. These studies will be co-led with Masaoki Kawasumi, MD, PhD (Acting Assistant Professor). The goal of these NIH-funded studies is to elucidate molecular mechanisms by which cells sense UV-induced DNA lesions (CPD and 6-4PP) and activate biological processes such as ATR-Chk1 checkpoint signaling, DNA repair, and mutagenic translesion synthesis and to dissect the molecular mechanisms by which caffeine prevents multiple types of skin cancers. Also, we will elucidate a mechanism of action of “MARPIN”, a novel ATR pathway inhibitor we discovered. Our approaches include cell culture, flow cytometry, DNA replication track analysis, Western blot analysis, chromatin immunoprecipitation (ChIP), proteomics, next-generation !
sequencing, and novel and established mouse genetic models. Highly motivated applicants should have research experience in cell biology, molecular biology, signal transduction, and/or chemical biology. Applicants should have good written and oral communication skills. Applicants for a postdoctoral position should possess an MD and/or PhD degree. Salary will be commensurate with experience and based on NIH and the University of Washington guidelines. Applicants should submit a letter of interest, CV, and the names of three potential references electronically to Dr. Kawasumi (kawasumi@uw.edu). Please visit our lab website at www.pnlab.org for more details on our research.

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Masaoki Kawasumi, MD, PhD
Acting Assistant Professor
University of Washington Medicine at South Lake Union
Department of Medicine/Division of Dermatology
Dr. Nghiem's Laboratory
850 Republican St, Rm 242
Seattle, WA 98109-4714
Phone: 206-221-4594
FAX: 206-221-4364
E-mail: kawasumi@uw.edu
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