A postdoctoral fellowship position(s) supported by NIDDK, CCHMC Academic Research Council and Burroughs Wellcome Fund are available in the laboratory of Dr. Senad Divanovic at the Cincinnati Children’s Hospital Medical Center in the Division of Immunobiology.
Our research program focuses on the role of immune response in inflammation and metabolism. Our expertise in pathways that regulate innate immunity― developed through the pursuit of studies ranging from reductive analysis of TLR ligand signaling to the role of IL-17 axis in experimental models of obesity and infection― have spearheaded the projects aimed at defining the role of the immune mediators in the development and progression of obesity and obesity-associated sequelae (e.g., diabetes, NAFLD). Current projects in the lab include:
• The role of IL-17 axis in obesity and pathogenesis of non-alcoholic fatty liver disease
• The role of Immune axes in regulation of energy metabolism and obesity development
• The role of inflammation in induction of parturition
• The role of environmental factors, and temperature specifically, as a critical modulator of animal physiology and immunology in disease development and progression
• Discover novel immune-metabolic pathways and genomic regulatory networks underlying obesity and related metabolic comorbidities in adolescents.
Recently we have illustrated the first evidence for a critical role for IL-17RA signaling in driving NAFLD progression, as well as the first report of a role for microbe-driven IL-17 production in exacerbating hepatocellular damage in NAFLD (Harley IT et. al., Hepatology 59:1830). Current studies are focused on defining the cellular and molecular mechanisms underlying the regulation of NAFLD pathogenesis by the IL-17 axis.
Further, we have recently shown that housing animals at thermoneutrality significantly alters animal physiology and immune response―something that allows us to develop new animal-models of human disease (Stemmer K et. al., Int J Obes 39:791). Current studies are focused on defining the cellular and molecular mechanisms underlying the ability to thermoneutral housing to modulate, immune responses, intestinal microbiome, obesity and NAFLD pathogenesis through regulation of transcriptional networks.
Of note, current projects are directly associated with translational research endeavors with a focus on an in depth analysis of the interplay between immune responses, obesity-associated sequelae and the outcomes of bariatric surgery in adolescents.
The position will provide a unique exposure to the use of animal models of obesity and obesity-associated sequelae and validation of the relevance of such findings in obese humans. Further, the fellowship will encompass a multidisciplinary training in immunology, metabolism, molecular and cellular biology, and transcriptional networks.
Additional details are available at the following link: http://www.cincinnatichildrens.org/research/divisions/i/immunobiology/labs/divanovic/default/
Candidates should hold a doctoral degree with a background in molecular biology, metabolism or immunology. Candidates must have proficiency in verbal and written English. Candidates with an interest in the position should send their CV and contact information for 3 references to: senad.divanovic@cchmc.org.

追加情報です。Dr. Divanovicは、Immuno-metabolism研究で頭角を現し、論文での成果はもちろん、NIH RO1を含む様々なグラントを獲得をし、勢いにのっている研究者です。また、素晴らしいMentorでもあり、研究室はとても活気に溢れ、充実した研究環境が整っています。興味のある方は、Dr. Divanovicに直接ご連絡ください。また、質問などありましたら、Dr. Divanovicとシンシナティ小児病院にて共同研究を行っている私（中村能久: Takahisa.Nakamura@cchmc.org（日本語可））にお問い合わせください。