Research Fellow: Molecular Endocrinology
Work at Carlos Ibanez laboratory focuses on understanding the functions and signaling mechanisms of growth factors and their receptors in nervous system function and metabolic regulation, for the development of better therapies to neurodegenerative and metabolic disorders. Carlos Ibanez is Professor at the Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore. Information about Carlos Ibanez research can be found at www.carlosibanezlab.se/NUS.
Postdoctoral fellows are currently being recruited to advance research on growth factor receptor signaling and function in metabolic regulation of fat deposition, adipose tissue function, CNS regulation of metabolism, and obesity. In our latest paper, we reported that the sensitivity of fat cells to signals that increase the breakdown of fat is linked to the TGFbeta superfamily receptor ALK7. This discovery, published recently in eLife (http://elifesciences.org/content/3/e03245), suggests that ALK7 is a promising new target for strategies to treat human obesity.
We are seeking talented, innovative and enthusiastic researchers with a PhD awarded within the last 5 years to extend this and related research and advance novel therapeutic opportunities. We will only consider candidates with documented expertise in molecular and cellular endocrinology, metabolic research and mouse genetics, and/or hands-on experience on TGFbeta signaling. Candidates lacking expertise in any of those two areas will not be considered.
The laboratory is well-funded and is located in one of the most vibrant research environments in South East Asia, offering many exciting opportunities for career development.
Applications, including CV, list of publications and statement of future interests should be sent to Prof. Carlos Ibanez (phscfi@nus.edu.sg). Applicants should arrange to have at least two confidential letters of reference sent independently by referees to this email address.
Funding is available for an initial period of 2 to 3 years, starting any time during 2015.
Deadline is December 12, 2014.

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コーネル大学医学部（ニューヨーク市内）ポスドク募集
骨免疫学・破骨細胞の分化的研究

An NIH funded postdoctoral position is immediately available in the laboratory of Dr. Zhao at the Hospital for Special Surgery, Weill Medical College of Cornell University in the New York City.
Ongoing studies include identification of novel players and regulatory mechanisms of osteoclastogenesis and bone metabolisms in the physiological and pathological settings in osteoimmunology field, an exciting interdisciplinary research field linking bone biology and immune system. We apply cutting edge cellular and molecular techniques including RNAseq and ChIPseq and use various mouse models to accomplish the study. Relevant publications: Nature Medicine, 15 (9):1066-71, 2009; Journal of Experimental Medicine, 209(2):319-34, 2012; Journal of Clinical Investigation, 124 (11):5057-73, 2014.
Qualified candidate must have a Ph.D. and/or M.D. in bone biology, molecular biology or a related field and have a record of peer reviewed publications. The ideal candidate will have expertise in bone biology, histology, molecular cloning, chromatin/protein immunoprecipitation, and manipulating genetic mutant mice and in vivo models. Familiarity with microarray or sequence analysis is preferred. High level of motivation and independence and the ability to think critically are expected. Excellent organization and time management skills are required as well as strong interpersonal skills. PhD candidates expected graduation soon are also encouraged to apply.
Competitive salary and an excellent benefits package (Medical, Dental and Life insurances) are available and will commensurate with experience and accomplishments.
Full applications including curriculum vitae, a brief summary of past, current and future research interests and accomplishments (1-2 paragraphs), selected reprints of publications, three references and expected availability date should be submitted via email to:
Baohong Zhao, DMD, PhD
Assistant Professor
Department of Medicine
Weill Medical College of Cornell University
Assistant Scientist
Arthritis and Tissue Degeneration Program
Hospital for Special Surgery
535 E70th Street, New York
NY10021 USA
Phone: (212) 774-2772
Email: baohongzhao1@gmail.com

Institution information:
Hospital for Special Surgery (HSS) is affiliated with Weill Medical College of Cornell University and involved in the exciting multi-institutional area comprising Cornell, Memorial Sloan-Kettering Cancer Center and Rockefeller University. Extensive collaborations, regular seminars, research-in-progress talks, journal clubs and retreats in this area provide exclusive research environment and training platform for enthusiastic candidates at their early career stages. HSS is also a world-renowned leading clinical and basic research center for the study of rheumatic and musculoskeletal diseases.

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以前所属していたHorng’s Labで新規ポスドク採用を行っておりますのでご案内させていただきます。
Dr Horngは自然免疫のスペシャリストで特にマクロファージのcell biologyを中心に行っております。現在のテーマは下記にありますようにmetabolism におけるマクロファージの役割と、代謝によるマクロファージの活性化および分化誘導に関して研究を行っております。また一方でカスパーゼ１をターゲットにインフラマソーム活性化時における細胞内シグナル活性および細胞死との関連を検討しております。
現在、ちょうどポスドクの入れ替えがあり新規ポスドクを探しておられます。
（私自身も10月でラボを離れています）

採用基準に関しては下記の詳細をご覧ください。

私自身もこのサイトを通じてラボに所属し、英語が不慣れな中、非常に丁寧に教えていただき２年間の期間を終え移動となっております。自然免疫やメタボリズムに興味がある方ご質問などありましたら気軽にご連絡ください。私自身ラボを離れていますので最終的な連絡は下記のDr. Horngに直接していただければ幸いです。
もし、日本語でご質問などがございましたら私宛にご連絡いただいても構いません。
可能な範囲でお答えいたします。

長洲　一　(zajiten1@gmail.com)

Dr. Tiffany Horng at the Department of Genetics & Complex Diseases and Immunology & Infectious Diseases in Harvard School of Public Health is looking for an outstanding postdoctoral fellow. We have recently shown that metabolic signaling pathways can regulate macrophage activation, and aim to further elucidate metabolic control of macrophage activation and effector responses. In another line of investigation, we seek to pursue our studies of inflammasome biology, including activation, regulation, and effector functions.

Candidates should have a background in innate immunity, immunology, and or immunometabolism, and should be skilled in cell biology, molecular biology, and basic mouse work, as demonstrated in their publication record. Candidates must have a Ph.D. or M.D. degree.

Please submit application, including a cover letter, CV and names and contact information of at least 3 references to:

Tiffany Horng, Ph.D.
Assistant Professor
Department of Genetics and Complex Diseases
Harvard School of Public Health
655 Huntington Ave, II-115
Boston, MA 02115
thorng@hsph.harvard.edu

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ボストン大学医学部薬理学教室にて博士研究員（Post-doctoral Fellow）を一名募集致します。当研究室は神経免疫細胞であるマイクログリアに関連したアルツハイマーやパーキンソン病などの精神神経疾患の基礎研究が中心です。担当者の研究内容は病原性蛋白の拡散を遺伝子変異マウスモデルを用いて解析します。神経免疫学は近年目覚ましい進歩がみられ、基礎と臨床応用研究で注目されている領域です。

採用時期：２０１5年1月から随時
応募人数：１人
募集期間：適任者が決まり次第締め切ります。
待遇：応募者の経験ならびにBUSMの規定に準じます。
応募資格：上記の研究に興味のあるPhDまたはMD, PhD取得者、あるいは着任までに取得見込みの大いにやる気のある方。特に神経精神疾患マウスモデルを用いた基礎研究の経験を持つ方は歓迎です。
応募書類：1.CV、 2.今までの研究概要およびこれからの研究への興味、 3.推薦者２名 以上の連絡先（Eメールでお送りください）

送付先：
Tsuneya Ikezu, M.D., Ph.D.
Professor, Department of Pharmacology and Neurology
Alzheimer's Disease Center
Boston University School of Medicine
Boston, MA 02118, USA
Email: tikezu@bu.edu
Website: http://www.bumc.bu.edu/busm-pm/fac/faculty/ikezu/

参考文献 :
1. Jun G, et al. PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation. Ann Neurol. 2014 Sep;76(3):379-92.
2. Ikezu S, et al. Tau-tubulin kinase. Front Mol Neurosci E-pub. 2014
3. Asai H, et al. Accelerated neurodegeneration and neuroinflammation in transgenic mice expressing P301L tau mutant and tau-tubulin kinase 1. Am J Pathol. 2014 Mar;184(3):808-18.
4. McKee AC, et al. The spectrum of disease in chronic traumatic encephalopathy. Brain. 2013 Jan;136(Pt 1):43-64. d
5. Vanderweyde T, et al. Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies. J Neurosci. 2012 Jun 13;32(24):8270-83.
6. Goldstein LE, et al. Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model. Sci Transl Med. 2012 May 16;4(134):134ra60.
7. Kiyota T, et al. FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders. Proc Natl Acad Sci U S A.  2011 Dec 6;108(49):E1339-48.

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