POST-DOCTORAL POSITION IN DNA REPLICATION

A position is available to study the regulation of initiation of DNA replication at the Institute of Human Genetics, CNRS Montpellier

Our research projects are focused on DNA replication origins from metazoans, their characteristics, the regulation of their activation, their relationship with cell identity. Our model systems include cell cultures from mouse and human cells, developmental systems (Xenopus and C. Elegans), as well as in-vitro DNA replication systems from Xenopus eggs.

The research project is based on our recent findings of sequence elements found common to replication origins. We would like to understand their function in the organization of chromosomes for DNA replication, and how they are assembled at the molecular level.

The Institute of Human Genetics (www.igh.cnrs.fr) is a modern large CNRS Institute located in the University and Hospital area in Montpellier. The working language is English. Fully endowed with state of the art scientific equipment, the IGH generates an excellent scientific environment for high quality and intensive scientific life. The city is one of the most lively and concentrated areas for research scientists in France.

We would be glad to receive applications from motivated scientists with a strong expertise in molecular biology and / or protein biochemistry.

The position is for at least 2 years, starting 2013.
Please submit a curriculum vitae and contact information of 2-3 referees to Marcel Méchali
Institute of Human Genetics, CNRS,
141 rue de la Cardonille, 34396 Montpellier, France
Tel : 33 (0) 434 359 917
Fax: 33 (0) 4 34 35 99 20
e-mail: mechali@igh.cnrs.fr
web: www.igh.cnrs.fr./equip/mechali/

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My laboratory has two major research interests: 1) investigation of molecular mechanisms underlying glioblastoma multiforme cancer stem cell behavior and 2) identification of novel signaling pathways controlling brain development.

 I am particularly focused on ubiquitin-proteasome system-specific mechanisms for both projects.

Washington University School of Medicine consistently ranks in the top 5 medical schools in the U.S.A. and is home to many of the United States' top scientists and physicians. The Department of Neurological Surgery in particular has a rich tradition of clinical and scientific excellence and is highly collaborative with other Departments in the medical center.

MD or PhD with expertise in molecular biology and biochemistry with a preference for new graduates or postdoctoral fellows with 2 or fewer 
years of experience.

Salary and benefits are based upon NIH 2012 guidelines
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-12-033.html

 and departmental guidelines. For full benefits including health, please see website
http://medschoolhr.wustl.edu/



Documents required for application

1) CV

2) 3 letters of recommendation and contact information for these references



Due date for application

May 1, 2013

Starting date for job
Summer 2013 with at least 2 year commitment



References



A.H. Kim, H. Yano, H. Cho, D. Meyer, B. Monks, B. Margolis, M.J.
Birnbaum, and M.V. Chao. Akt1 regulates a JNK scaffold during
excitotoxic apoptosis. Neuron 35(4): 697-709. 2002.



A.H. Kim and A. Bonni. Thinking within the D box: Initial 
identification of Cdh1-APC substrates in the nervous system. Mol Cell 
Neurosci. 34(3): 281-7. 2007.



A.H. Kim, S.V. Puram, P.M. Bilimoria, S. Keough, M. Wong, D. Rowitch,
and A. Bonni. A centrosomal Cdc20-APC pathway controls dendrite
 morphogenesis in postmitotic neurons. Cell 136(2):322-336. 2009.



Y. Yang, A.H. Kim, T. Yamada, B. Wu, P.M. Bilimoria, Y. Ikeuchi, N. de
la Iglesia, J. Shen, and A. Bonni. A Cdc20-APC ubiquitin signaling
 pathway regulates presynaptic differentiation. Science 326:575-8.
2009.



S.V. Puram, A.H. Kim, Y. Ikeuchi, A. Riccio, S. Koirala, J.T.
Wilson-Grady, A. Merdes, S.P. Gygi, G. Corfas, and A. Bonni. A Unique
 CaMKIIβ Signaling Pathway at the Centrosome Regulates Dendrite 
Patterning in the Mammalian Brain. Nat Neurosci 14(8):973-83. 2011.



Albert H. Kim, MD, PhD

Assistant Professor of Neurosurgery, Neurology, and Developmental Biology

Washington University School of Medicine

660 S Euclid Ave, Box 8057

St. Louis, MO 63110

Tel: 314-362-8443 
Fax: 314-362-2107

kima@wudosis.wustl.edu

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Postdoctoral Position in Epigenomics
The Division of Allergy and Immunology at Cincinnati Children’s Hospital Medical Center has an opening for a Postdoctoral Fellow. The Barski laboratory is focused on elucidating the mechanisms of epigenetic regulation involved in immune activation, tolerance and memory. The goal of the research is to understand how the epigenome shapes the immune response and whether it is possible to modulate immune response by targeting epigenetic mechanisms. The laboratory is utilizing and developing cutting edge wet-lab and computational methods based on the next-generation sequencing. Please see: Barski et al. Cell, 2007; Barski et al. Genome Research, 2009; Cuddapah et al. Curr. Op. Imm, , 2010.

The Division is a high-energy, dynamic, and interactive environment that is interested in recruiting self-motivated individuals with the drive to succeed and the desire to be competitive at the international level. Candidates with a strong background in molecular biology, epigenetics, bioinformatics and genomics are encouraged to apply. In particular, experience with methods such as foot-printing, chromatin and transcription assays, DNA methylation, ChIP-Seq, RNA-seq and NGS data analysis will be advantageous. An established track record (as evidenced by publications in peer-reviewed journals) is a significant plus.

Salary is competitive with an attractive benefits package that includes family health insurance, etc. For consideration, please send CV and contact information for three references to:

Artem Barski, Ph.D.
Cincinnati Children’s Hospital Medical Center
Division of Allergy and Immunology
3333 Burnet Avenue
Cincinnati, OH 45229
Email: barskilab@cchmc.org

In addition to world-class clinical care, Cincinnati Children's Hospital Medical Center is a leader in research that leads to better treatments for children. We are the second-highest recipient of grants from the National Institutes of Health for pediatric research.
Cincinnati is one of America’s historic river cities. The metropolitan population is nearly 2 million. The city has a diverse economy that includes a leading healthcare industry, a growing biomedical industry, major universities, a global culture and an excellent quality of life.
Cincinnati Children's Hospital Medical Center is an Affirmative Action/Equal Opportunity Institution. Women and Minorities are encouraged to apply.

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Postdoctoral Position: mechanisms of DNA damage response and telomere maintenance

One postdoctoral position will be open to study the link between DNA damage checkpoint response, telomere control and cell senescence at the International Center of Public Health (ICPH) starting April 2013.
The ICPH is merging into Rutgers University this summer.

Candidates must have strong backgrounds in molecular biology and biochemistry and have a desire to explore fundamental problems of biology. Our group is mainly using yeast cells but at the stage of expansion to the related research field using mammalian cells as well as yeast cells.

References: Science 294:867, 2001; Genes & Dev 17: 1957, 2003; Nature 424:1078, 2003; Current Biology16:586, 2006; Mol. Biol. Cell 18:2026, 2007; Molecular Cell 33:312, 2009, Mol. Cell Biol 31: 1959, 2011; Mol. Biol. Cell 23:347, 2012.

The ICPH building is located in close proximity to New York City. Many scientific and educational opportunities are available in the NY metropolitan area, as well as cultural, entertainment, outdoor and sports activities.
More information is available at
http://njmsmicro.umdnj.edu/index.php?option=com_content&task=view&id=111&Itemid=73

Interested candidates should send a cover letter and curriculum vitae with contact information for three references (name, address, phone and e-mail) by email to: Dr. Katsunori Sugimoto (sugimoka@umdnj.edu).

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新規のNIHグラント獲得に伴いT細胞分化における転写因子による遺伝子制御、エピジェネティック制御の研究に興味のあるポスドクを１名募集します。我々はこれまで、Runx, ThPOKをはじめとした胸腺でのT細胞の系列決定、あるは免疫反応におけるT細胞の機能に必須な転写因子の機能の研究を行ってきました。今後、これらの転写因子とそれらの会合分子の相互作用の機能的な解析を通して、細胞分化に過程で転写因子による一過性の遺伝子制御がいかにしてより安定的に維持されていくエピジェネティック制御に移行するのか、およびRunx, ThPOKと強調して機能する新規の転写因子の同定および機能解析を行うことによって、リンパ球発生での転写因子ネットワークの解明を目標とします。
博士過程を修了後２年以内、あるいは修了見込みで、分子生物学，生化学の実験手法を十分に習得されている方、とくにクロマチン、エピジェネティック研究の経験のある方は優先的に考慮します。
待遇：NIHガイドラインに従います。任期は特に定めませんが、着任後1-2年程度の時点での評価でそれ以降について決定します。
興味のある方は、CV、これまでの研究のサマリー（１ページ程度）、今後の研究の目標（１ページ程度）、および２名以上の推薦者の連絡先を下記宛にemailで送付してください。

Takeshi Egawa, M.D., Ph.D.
Assistant Professor
Department of Pathology & Immunology
Washington University School of Medicine
660 S. Euclid Ave., BOX 8118
Saint Louis, MO 63110
Email: tegawa@pathology.wustl.edu

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16 PhD Fellowships in Life and Natural Sciences

The International Max Planck Research School – Molecular Biomedicine (IMPRS-MBM) and the Cells in Motion Excellence Cluster (CiM) offer 16 PhD Fellowships in Life and Natural Sciences.

The CiM Graduate School and IMPRS-MBM - jointly run by the University of Münster and the Max Planck Institute for Molecular Biomedicine - offer interdisciplinary approaches to biomedical research with a strong emphasis on imaging. PhD projects range from the analysis of basic cellular processes to clinical translation, from the generation of mathematical models to the development of new imaging-related techniques and compounds.

Research areas:
Cell and Molecular and Biology
Developmental and Stem Cell Biology
Vascular Biology
Immunology
Microbiology
Neurobiology
In vivo Imaging
High Resolution Optical Imaging
Biophysics
Chemical Biology
Label Chemistry
Mathematical Modelling
and more.

Applications for the 3-year PhD program can be submitted from 1 March – 10 May 2013. Projects start in October 2013. Applications can only be submitted via our online system.

For online application and further information go to

www.cim-imprs.de.

The program offers excellent scientific and transferable skills training, a competitive tax-free fellowship and support with administrative matters, accomodation, visas etc. There are no tuition fees. The program language is English. We invite applications from highly qualified and motivated students of any nationality from biological sciences, chemistry, mathematics, computer sciences and physics. We are looking forward to your application for a PhD fellowship in Münster, "the world’s most liveable city" (LivCom Award 2004).

Contact: cim-imprs@uni-muenster.de

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Postdoctoral position - Structural basis of ubiquitin signalling

Postdoctoral position in the laboratory of Dr. Yogesh Kulathu at the MRC Protein Phosphorylation and Ubiquitylation Unit, The Sir James Black Centre, University of Dundee, Scotland.

A postdoctoral position is available in the newly established lab of Dr. Yogesh Kulathu to apply structural methods to gain insights into the molecular mechanisms underlying regulation of signalling enzymes by ubiquitylation. Polyubiquitylation regulates diverse cellular functions and eight different ubiquitin linkage types can be formed in cells. At present we only have limited knowledge of the cellular functions of some of these linkage types and the enzymes and mechanisms by which the different ubiquitin chain types are regulated. The lab uses an interdisciplinary approach to dissect ubiquitin-signalling to understand the underlying biochemical and structural mechanisms and genetic approaches to discover signalling nodes and pathways regulated by different ubiquitin modifications.

We are seeking an enthusiastic and highly motivated individual with experience in protein crystallography and wanting to work on interesting structural and mechanistic questions related to ubiquitin signalling. The work will involve X-ray crystallography and the laboratory has access to extensive crystallographic resources within the Unit and the College of Life Sciences, University of Dundee and is well equipped for protein production and purification.

In addition, the successful candidate will benefit from the cutting edge facilities in biochemistry, cell biology, drug discovery, and proteomics available within the College of Life Sciences.

This position is available for 3 years and the appointment will be made at Grade 7 (￡29,541 - ￡36,298).

MRC Protein Phosphorylation and Ubiquitylation Unit (PPU):

This project will be performed in the MRC Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU), based within the College of Life Sciences at the University of Dundee. The MRC-PPU is one of the world’s most renowned centres for research on protein phosphorylation and ubiquitylation (http://www.ppu.mrc.ac.uk/). Many world leading researchers in the field of signal transduction have trained within the MRC-PPU. The major aims of the MRC-PPU are to advance understanding of the role of protein phosphorylation and ubiquitylation in cell regulation and human disease, to facilitate the development of drugs to treat diseases caused by abnormalities in phosphorylation, to generate reagents and improve technologies. Another key remit of the MRC-PPU is to train the next generation of scientists who will advance our understanding in this crucial area of medical research. The MRC-PPU is in a beautiful location overlooking the estuary of the River Tay and embedded within the Col!
lege of Life Sciences at the University of Dundee which is one of the premier Life Sciences research centres in the world.

Candidate requirements:

• PhD with outstanding academic track record and at least one first authored publication in an internationally recognised peer-reviewed journal
• Experience in recombinant protein expression, purification, crystallization and structure determination is required. In addition a strong background in Biochemistry and an interest in Signal Transduction would be preferable
• Ability to work in a team, but able to plan and work independently
• Excellent communication skills and proficiency in English

How to apply:

To apply on-line please visit: www.dundee.ac.uk/jobs. If you are unable to apply on-line please contact Human Resources on (01382) 386209 (answering machine) for an application pack. Please quote reference number LS0296. Informal enquiries may be addressed to me at y.kulathu@dundee.ac.uk

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Dr. Yogesh Kulathuが、スコットランド、ダンディー大学で、２０１３年２月から新しい研究室を立ち上げました。
http://www.ppu.mrc.ac.uk/research/?pid=1001
ユビキチンによる細胞内シグナル伝達制御機構の研究を行っています。
現在、タンパク質のX線結晶構造解析を専門とする方 (LS0296)、
生化学、分子生物学、細胞生物学の手法を習得されている方 (LS0297)をそれぞれ１名を募集してます。
ご興味のある方は、こちらをご覧ください (reference number LS0296 and LS0297)。
www.dundee.ac.uk/jobs

日本語での質問等がございましたら、阿久津誠人 (akutsu@em.uni-frankfurt.de)までお気軽にお問い合わせください。

任期と給与：３年間、￡29,541から￡36,298
応募先
To apply on-line please visit: www.dundee.ac.uk/jobs.
If you are unable to apply on-line please contact Human Resources on (01382)386209 (answering machine) for an application pack.
Please quote reference number LS0296 and LS0297.
Informal enquiries may be made to Yogesh Kulathu at y.kulathu@dundee.ac.uk

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