AVAILABLE POSTDOC POSITION

A postdoctoral position is available at IFReC (Immunology Frontier Research Center), a unique Japanese and English speaking International environment, Osaka University, JAPAN for highly motivated individuals interested in vaccine and adjuvant (i.e. particulate adjuvanst) development research. Our laboratory mainly focuses on the understanding of innate immune responses to malaria infection in mouse models and human and developing new vaccines/adjuvants with a great interest to their mechanisms of action (see detailed information at the web site;
http://www.ifrec.osaka-u.ac.jp/en/laboratory/malariaimmunology/index.php). We’ve recently obtained a grant called “Adjuvant Database Project” (see http://adjuvantdb.nibio.go.jp/about.html ) with a group of researchers from NIBIO (Leader is Prof. Ken Ishii).

The position is available from April 1st, 2013 and for 1 year from the starting time, renewable up to a total of three years depending on the successful progress. The candidates must obtain PhD or MD with a strong background in immunology/molecular biology. The experiments will include handling several genetically deficient mice for immunizations and various immunological techniques such as FACS analysis, PCR, ELISA, western-blotting etc.
Applicants should send, CV, a letter explaining career plans, and contact information of 2 referees to:

Cevayir Coban MD/PhD
Associate Professor
Laboratory of Malaria Immunology
Immunology Frontier Research Center (iFREC)
Osaka University

3-1 Yamada-oka, Suita City, Osaka 565-0871 JAPAN
081-6-6879-8303 (Tel & Fax)
ccoban@biken.osaka-u.ac.jp

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【職種】ポスドク研究員

【研究機関】シンガポール　テマセク生命科学研究所（参照：http://www.tll.org.sg/）

【研究室の概要】シンガポールの国際的研究機関「テマセク生命科学研究所」では、生物現象の本質を分子細胞レベルで解明することを目標に、幅広い研究活動を行っています。当該研究所で昨年８月からスタートした研究室（主任研究員：茂木文夫）では、テマセク生命科学研究所とシンガポール国立大学・メカノバイオロジー研究所との密接な共同研究体制を利用して、「受精卵が非対称化することにより体細胞と生殖細胞を作り分ける仕組みを理解する」研究を行っています。現在はポスドク一人、技官一人の小さい研究室ですが、ポスドク研究員を更に一名募集します。（参照：http://www.tll.org.sg/research/research-group-leaders/）

【職務内容】 受精卵は、受精をきっかけとして細胞内をふたつの領域に区画化し、この空間的非対称性を使って細胞種および機能の多様性を生み出します。この受精卵の非対称化は、胚発生におけるボディープランの基盤となるにも関わらず、一連の過程を制御する仕組みは未だ明らかではありません。本研究プロジェクトでは、線虫 C. elegans 受精卵をモデル系とし、受精卵が非対称化することで体細胞と生殖細胞を作り分ける分子メカニズムの理解を目標とします。発生遺伝学と生化学的を基盤とし、最先端の分子細胞イメージング・解析技術を最大限に活用した、統合的なアプローチを行います。参考文献を以下に掲載しますが、更に詳細な研究プロジェクトの内容については気軽に問い合わせして下さい。
Motegi et al. (2011) Nat. Cell Biol 13: 1361-1367
Zonies, Motegi, et al. (2010) Development 137: 1669-77
Motegi & Seydoux (2007) J. Cell Biol 179: 367-369
Motegi & Sugimoto (2006) Nat. Cell Biol 8: 978-985
Motegi et al. (2006) Dev. Cell 10: 509-520

【待遇と給与】常勤（任期あり）、テマセク生命科学研究所の規定に準じます

【応募資格】PhD取得者、または取得見込みの方。第一著者の英語論文を一報以上持っていること。

【応募書類】１）履歴書、２）研究業績目録とこれまでの研究概要（A4一枚程度）、３）志望動機と今後の抱負（A4一枚程度）、４）照会可能な方３名の氏名および連絡先 、 以上４種の書類を下記e-mail宛に送付してください（fmotegi@tll.org.sg）。

【選考内容】テマセク生命科学研究所の規定に準じます（書類選考後、面接とセミナー）。

【連絡先】ご質問等はe-mailで気軽に問い合わせして下さい（fmotegi@tll.org.sg）。

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Postdoctoral Position in Drosophila Neurobiology

A postdoctoral position is available in the laboratory of Kyunghee Koh at Thomas Jefferson University in Philadelphia to study the molecular and cellular basis of sleep regulation in Drosophila. We are interested in identifying novel genes and neural circuits required for sleep and circadian rhythms. Sleep is an essential, evolutionarily conserved process, and Drosophila sleep is an exciting new research area with many opportunities. Highly motivated individuals with a recent Ph.D. in neurobiology, genetics, biochemistry, cell biology, and/or molecular biology and a strong publication record are encouraged to apply. To apply, please send CV, a letter describing research experience and career goals, and contact information for three references to FlySleepLab@gmail.com

Selected publications:

Jepson JEC, Shahiddullah M, Lamaze A, Peterson D, Pan H, Koh K. (2012). dyschronic, a Drosophila homolog of a deaf-blindness gene, regulates circadian output and Slowpoke channels. PLoS Genetics. 8(4):e1002671.
Wu MN, Joiner WJ, Dean T, Yue Z, Smith CJ, Chen D, Hoshi T, Sehgal A, Koh K. (2010). SLEEPLESS, a Ly-6/neurotoxin family member, regulates levels, localization, and activity of Shaker. Nature Neuroscience, 13, 69-75.
Koh K, Joiner WJ, Wu MN, Yue Z, Smith CJ, Sehgal A. (2008). Identification of SLEEPLESS, a novel sleep promoting factor. Science, 321, 372-376.
Koh K, Zheng X, Sehgal A. (2006). JETLAG resets the Drosophila circadian clock by
promoting light-induced degradation of TIMELESS. Science. 312, 1809-1812.
Koh K, Evans JM, Hendricks JC, Sehgal A. (2006). A Drosophila model for ageassociated
changes in sleep:wake cycles. Proceedings of the National Academy of
Sciences, USA. 103, 13843-13847.

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当研究室のテーマは、 生命機能と病態における細胞エネルギーの制御機構の解明と治療へ向けた応用です。乳癌・肺癌などの脳転移、代謝疾患に向けたトランスレーショナルな研究を展開していきます。腫瘍や肝臓・筋肉代謝の研究経験のある方や、エピジェネティクス・転写制御、またはHPLC等分析化学、生化学的解析のバックグランドがある方を募集しております。

詳しくはラボのホームページをご参照ください。
http://www.thesasakilab.org/index_j.php

対象は博士研究員または学生留学希望の方です。ご興味ある方は、まずはお気軽にご連絡ください。
atsuo.sasaki[at]uc.edu
[at]を＠に変換されてください。

佐々木 敦朗
Atsuo T. Sasaki, Ph.D.
Assistant Professor
Chair: BTC Translational Research committee
University of Cincinnati, College of Medicine: Dep. of Internal Medicine
UC Cancer Institute: Brain Tumor Center (BTC)
UC Neuroscience Institute: Dep. of Neurosurgery
Tel: 513-558-2160
Fax: 513-558-6703
Email: atsuo.sasaki [at] uc.edu
Address:　Vontz Center Rm1234, 3125 Eden Ave, Cincinnati, OH 45267-0508

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　New York、Memorial Sloan-Kettering Cancer CenterのJames Hsieh研究室では、現在Kidney CancerのTranslational Researchプロジェクトを拡大しており、ポスドクを募集しています。応募資格は、PhD取得者で、分子生物学・生化学・腫瘍の移植モデルなどの経験と技術を持つ、意欲ある方です。特にCancer Stem Cell Researchを進める技術と意欲のある方を希望しています。
　応募方法は、研究業績一覧を含めた英語のCVと、推薦者3名のリストを送って頂くことになりますが、まずは現ポスドクの新妻秀剛までお気軽にメール（niizumah@mskcc.org）でお問い合わせください。もちろん日本語で結構です。

研究室HP:
http://www.mskcc.org/research/lab/james-hsieh
業績(Pubmed):
http://www.ncbi.nlm.nih.gov/pubmed?term=Hsieh%20JJ%20AND%20Cheng%20EH
PI:
James J. Hsieh, M.D., Ph.D.
Associate Member, Human Oncology and Pathogenesis Program
Memorial Sloan-Kettering Cancer Center
1275 York Avenue, Box 20
New York, NY 10065, USA

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A post-doctoral position is available immediately in the Wei lab at Dept. of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School. The lab’s focus is on understanding how Ubiquitin E3 ligase APC (Wei et al., Nature 428: 194, 2004; Gao et at Nature Cell Biology 11: 397, 2009; Wan et al, Molecular Cell 44: 721, 2011) and SCF (Wei et al., Cancer Cell 8: 25, 2005; Inuzuka et al, Cancer Cell 18:147, 2010; Inuzuka et al, Nature 471:104, 2011; Gao et al, Molecular Cell 44: 290, 2011; Inuzuka et al, Cell 150(1): 179, 2012) activities contribute to cell cycle regulation and subsequent tumor formation. Future projects in the lab engage the use of biochemistry, molecular biology and genetic approaches, cell culture techniques and potentially mouse modeling. Therefore, energetic applicants with strong experimental background in biochemistry, molecular and cellular biology and/or genetics are encouraged to apply.

Dr. Wei is looking for self-motivated individuals to become involved in the challenging and rewarding environment of the laboratory. If interested, please send your CV/resume and three references to

Wenyi Wei, Ph.D
Associate Professor
Dept. of Pathology, Harvard Medical School
Beth Israel Deaconess Medical Center
CLS-637, 330 Brookline Avenue
Boston, MA 02115
Phone: (617) 735-2495
Email: wwei2@bidmc.harvard.edu

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Two Postdoctoral Fellow positions are currently available in the Lefebvre laboratory in the Department of Cellular and Molecular Medicine at the Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, USA (http://www.lerner.ccf.org/cmm/lefebvre/).

The goals of the available research projects are to elucidate molecular mechanisms driving cell fate and function in the skeleton. These projects are aimed at providing new, important insights into mechanisms that contribute to normal skeleton development and adult homeostasis, and that are deregulated in skeletal dysplasias and adult degeneration diseases. The unifying theme of projects in the laboratory is the regulation and mode of action of Sox transcription factors and their upstream regulators and downstream targets in the skeleton. The realization of these projects will involve state-of-the-art approaches in cell and molecular biology, genomics and proteomics, and mouse genetic models.

Successful candidates will demonstrate dedication to pursue a research career in the skeleton field. The candidates will have a Ph.D. in molecular biology, genetics, developmental or cell biology, with a scientific focus on a skeleton-related topic, and will have several first-author publications in top-tier, peer-reviewed journals.

The Lerner Research Institute and Department of Cellular and Molecular Medicine provide a prosperous and resourceful environment for biomedical research, with state-of-the-art facilities and competitive salaries, and participate in multiple programs for pre- and post-doctoral trainees. As an equal opportunity and affirmative action employer, the Cleveland Clinic recognizes the power of a diverse community and encourages applications from individuals with varied experiences, perspectives, and backgrounds.

To apply, please email your curriculum vitae, contact information for three references, and an essay describing research expertise and career goals to Véronique Lefebvre, PhD (lefebvv@ccf.org).

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Immunology Post-doctoral Position (1/3/2012)

下記はDr. Hui Hu lab （Assistant Professor, The Wistar Institute, Philadelphia）のポスドク募集です。Dr. Hui Huはnaive T cellを中心とした免疫領域にて数々の論文を排出しております。（Blood 115:510, Nat Immunol 12:544）
2013年4月からの募集を希望されております。Ph.D.もしくはM.D.取得および取得予定の方で、特に免疫領域に明るい人材を求めており、分子生物学的手法•FACS経験はもとより、Englishによるコミュニケーションがとれる方を望まれております。
ご興味がある方はCVおよびcover letterを下記宛に送付頂ければ幸いです。
○ Hui Hu, Ph.D., Assistant Professor, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, E-mail: hhu@wistar.org

なおDr. Hui Huからの募集を下記に添付しております。研究室の詳細（論文業績等）は下記サイトより参照頂けます。
http://www.wistar.org/our-science/scientists/hui-hu-phd
http://www.med.upenn.edu/apps/faculty/index.php/g5455356/p8183878
http://www.med.upenn.edu/apps/faculty/index.php/g2000341/p8183878

A POSTDOCTORAL POSITION will be open in the research group of Dr. Hui Hu starting April 2013. The research project aims to study the molecular mechanisms underlying a newly discovered T cell quiescence regulation (Blood 115:510, Nat Immunol 12:544), and to develop novel autoimmune disease and infectious disease models.

The postdoctoral candidate will have recently acquired a Ph.D. and/or M.D. preferably in immunology with technique expertise in flow cytometry and molecular biology. Strong background in transcriptional regulation and/or signaling pathways is desirable. The Wistar Institute, a world-renowned leader in biomedical research, will provide an outstanding intellectual environment and state-of-art facilities.

To apply, please submit your curriculum vitae and cover letter including names and contact information of three references to, Hui Hu, Ph.D., Assistant Professor, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, E-mail: hhu@wistar.org

For more information about The Wistar Institute visit our website at www.wistar.org.
EOE/AA/M/F/D/V.

The Wistar Institute is an international leader in biomedical research, dedicated to discovering the causes and cures for major diseases and the development of vaccines. Affiliated with the University of Pennsylvania, the Wistar Institute has a highly collaborative research environment. Wistar also enjoys a close working relationship with the Children’s Hospital of Philadelphia and many other medical research organizations in the greater Philadelphia area. Founded in 1892 as the first nonprofit biomedical research institute in the country, The Wistar Institute maintains its status as an independent research center and has long held the prestigious Cancer Center designation from the National Cancer Institute.

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オハイオ州立大学脳神経外科、脳腫瘍幹細胞研究室のNakano Labでは、新たに１人、ポストドクトラルフェローを募集します。当研究室は２００６年にUCLAで立ち上げ、２００９年にOSUに移動して、脳腫瘍のシグナル伝達系の解析と、エピジェネテッティクス・ジェネティックス解析、得られた知見からの臨床治験のプロトコール作成と患者のリクルートなど、基礎研究から臨床応用まで幅広い医科学臨床研究を行っております。当研究室は決して大きなラボではありませんが（ポスドク１人、ヴィジティングフェロー２人、テクニシャン１人、医学部生１人）、米国内とカナダ、ヨーロッパ、韓国を中心に２０研究室を超える施設と共同研究を立ち上げており、がん研究における最先端のテーマについて、直接間接的に最先端の知見に接することができます。

直近の論文は以下を参照ください。

２０１１年
1. Siomycin A depletes brain tumor stem cells partly through the MELK-mediated pathway. Nakano I (corresponding author), Inagaki A, Watanabe M, Lam D, Leung C, Visnyei K, Okemoto-Nakamura Y, Liang R, Mischel P, and Kornblum HI. Neuro-oncology 2011. 13(6):622-34.
2. Method for Novel Anti-Cancer Drug Development using Tumor Explants of Surgical Specimens. Joshi K, Demir H, Miyazaki T, Yamada R, Ray-Chaudhury A, Nakano I. Journal of Visualized Experiment 2011. 53 doi: 10.3791/2846
3. CD44v6 regulates brain tumor stem cell growth partially through the AKT-mediated pathway. Jijiwa M, Demir H, Gupta S, Leung C, Joshi K, Orozco N, Huang T, Yildiz VO, Shibahara I, de Jesus JA, Yong WH, Mischel PS, Fernandez S, Kornblum HI and Nakano I. PLoS ONE 6(9): e24217. doi:10.1371/journal.pone.0024217
4. A molecular screening approach to identify and characterize inhibitors of glioblastoma multiforme stem cells. Visnyei K, Onodera H, Saigusa K, Damoiseaux R, Petrosyan S, De Vries D, Ferrari D, Saxe J, Panosyan E, Masterman-Smith M, Mottahedeh J, Huang J, Sabatti C, Nakano I and Kornblum HI. Molecular Cancer Therapeutics 2011 Oct;10(10):1818-28
5. Cancer Stem Cells in Pediatric Brain Tumors. Lasky JL, Choe M, and Nakano I. Cancer Stem Cells and Therapy 2009 Dec; 4(4):298-305
6. Editorial Finding drugs against CD133(+) glioma subpopulations. Nakano I, Chiocca EA. J Neurosurg. 2011 Mar;114(3):648; discussion 648-50.
7. Cancers and Cancer Stem Cells. Nakano I and Saya H No Shinkei Geka. 2010 Aug. Japanese
8. Brain tumor stem cells. Lasky JL and Nakano I. Current Signal Transduction Therapy 2011 [in press]
9. Glioma stem cells and their therapy resistance. Mangum R and Nakano I. Journal of Carcinogenesis and Mutagenesis 2011 [in press]

２０１２年
1. Telomestatin impairs glioma stem cell survival and growth trough the disruption of telomeric G-quadruplex and inhibition of the proto-oncogene, c-Myb. (with the cover picture) Miyazaki T, Pan Y, Joshi K, Purohit D, Hu B, Demir H, Mazumder S, Okabe S, Yamori T, Viapiano M, Shin-ya K, Seimiya H, and Nakano I. Clin Cancer Res 2012 Mar 1;18(5):1268-80.
2. Laminin alpha 2 enables glioblastoma stem cell growth. Lathia JD, Li M, Gallagher J, Hall PE, Hale JS, Wu Q, Levy E, Venere M, M. Rani S, Huang P, Bae E, Selfridge J, Cheng L, Guvenc H, McLendon RE, Nakano I, Sloan AE, Bao S, Lai A, Gladson C, Bredel M, Hjelmeland AB, Rich JN. Annals of Neurology (in press)
3. Suppression of peroxiredoxin 4 in glioblastoma cells increases apoptosis and reduces tumor growth. Kim TH, Song J, Alcantara S, Murnan E, Liyanarachchi S, Palanichamy P, Yi JY, Viapiano MS, Nakano I, Yoon SO, Wu H, Parada LF, and Kwon CH. PLoS ONE (in press)
4. Blockade of EGFR signaling promotes glioma stem-like cell invasiveness by abolishing ID3-mediated inhibition of p27(KIP1) and MP3 expression. Jin X, Jin X, Sohn YW, Yin J, Kim SH, Joshi K, Nam DH, Nakano I, Kim H. Cancer Lett. 2012 Sep 27. pii: S0304-3835(12)00542-3. doi: 10.1016/j.canlet.2012.09.005.
5. A streamlined protocol for the use of the semi-sitting position in neurosurgery: A report on 48 consecutive procedures. Ammirati M, Lamki TT, Shaw AB, Forde B, Nakano I, Mani M. J Clin. Neurosci.[in press]
6. Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin/Ran protein complex. Guvenc H*, Pavlyukov MS*, Kurt H, Joshi K Banasavadi-Siddegowda YK, Mao P, Hong C, Yamada R, Kwon CH, Kitange G, Park IH, Sarkaria JN, Li C, Shakhparonov MI, Nakano I. Clin Cancer Res [in press]
7. Tumor-specific activation of the c-JUN/MELK pathway regulates glioma stem cell growth in a p53-dependent manner. Gu C, Banasavadi-Siddegowda YK, Joshi K, Nakamura Y, Kurt H, Gupta S, and Nakano I. Stem Cells [in press]
8. Glioma Stem Cells: Their Role in Chemoresistance. Yamada R and Nakano I. World Neurosurgery 2012 [in press] doi:10.1016/j.wneu.2012.01.004
9. Characteristics of Brain Tumor Stem Cells and the Rationale for Applying Tyrosine Kinase Inhibitors as Potential Targeting Agents. Michael R. Mangum MR, Purohit D, and Nakano I. Recent Patents on Regenerative Medicine 2012 [in press]
10. Fluorescence-Guided Brain Tumor Surgery. Smith L and Nakano I. World Neurosurgery 2012 [in press]

現在、当研究室からの論文が１報、Stem Cellsにminor revision, １報、PNASにminor revision、そのほかマイナージャーナルにいくつか投稿中となっております。そして、２０１３年の終わりまでには、cancer stem cellに関するゲノム異常の新規知見についてNature journalに２報投稿を目指しております。

また共同研究者として、脳腫瘍研究で世界をリードする研究室(e.g. UCSF, Cleveland Clinic, Cornell University, Northwestern University, Sloan Kettering Cancer Center, UCSD)とともに、１報がCancer Cellにminor revision、1報がGenes & Developmentにminor revision, １報がCellにmajor revision, １報がCancer Cellにmajor revision, １報がMCBに投稿中など、その他複数が発表へと向かっております。

基本的に受け入れたい方は、ガッツがあって米国（かそのほかの国）で独立を目指す能力のある方です。我こそと思われる方は、ぜひ連絡ください。グラントの取得、グリーンカードの取得、ファカルティーの職の取得など、数年前に私自身が通ってきた道を参考に、可能な範囲のサポートをします。技術的には、cell culture, stem cell culture, FACS, cell sort, transfection, lentiviral infection, siRNA/shRNA, site-directed mutagenesis, ChIP, IP-Western, qRT-PCR, ELISA, xenograft, mouse drug treatment, slice culture of patient tumorsなどを扱っていただきます。

有給で受け入れる方は、PhDを有し、first authorでcompetitiveな雑誌に論文がある方と限っております。無給で６－１２ヶ月トレーニングを受けて、次のステップを目指す方も喜んで受け入れます。

コロンバスは東海岸、西海岸と比較して6割程度の生活費で、ポスドクの給料でも家族を養える環境です。また、HONDAの拠点でもあり、日本人コミュニティーもしっかりしています。腹の座った方の応募をお待ちしております。

中野伊知郎
ichiro.nakano@osumc.edu

＊＊
Ichiro Nakano,MD, PhD
Associate Professor,
Director of Neural Cancer Stem Cell Program,
James Comprehensive Cancer Center,
Department of Neurosurgery,
The Ohio State University
Phone: 614-292-0358
Fax: 614-688- 4882

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Postdoctoral fellow position

A postdoc fellow position is open immediately to study tRNA biology, using biochemical, biophysical, and bioinformatics methods. The focus is on tRNA biology of mammalian mitochondria, which is associated with the development of many human cardiovascular and neurological diseases.

Ideal candidates must have experience in biochemical and biophysical experience and must have used quantitative measurements. Experience in fluorescence analysis of proteins or nucleic acids, in enzyme assays, RNA isolation, nucleic acid preparation, and kinetic concepts are important. The position is in Department of Biochemistry and Molecular Biology of Thomas Jefferson University, located in the center city of Philadelphia, USA, surrounded by historical landmarks of the US founding history. The lab has a strong infrastructure for promoting research and for networking with collaborators around the world. We have a strong track record of publications and we encourage teamwork and leadership and participation in domestic and international meetings. This is a great place to build a successful research career.

Please visit our website: www.houlaboratory.org/home.html

Please send CV with a list of references containing names, email addresses, and phone numbers to:
Professor Ya-Ming Hou
Department of Biochemistry and Molecular Biology
Thomas Jefferson University
233 South 10th Street, BLSB 220
Philadelphia, PA 19107
Email: ya-ming.hou@jefferson.edu

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