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Postdoctoral Fellow – Genomic Instability and Fanconi Anemia

A postdoctoral position is immediately available in the laboratory of Dr. Sobeck at the University of Minnesota, Minneapolis. Our laboratory focuses on elucidating the roles of the enigmatic Fanconi Anemia proteins in protecting genome stability throughout the cell cycle. We use a combination of human cell-based assays, cell-free Xenopus laevis egg extracts, and in vitro biochemical assays to decipher how different FA pathway members communicate with other genomic caretaker proteins to prevent chromosomal instability. This position will work on elucidating physical and functional interactions between FA proteins and the ATR/ATM-regulated signaling pathways under normal and perturbed cellular conditions. We are seeking a highly dedicated scientist with a strong background in mechanisms of DNA replication and repair, and a genuine passion for dissecting the complex DNA damage response mechanisms that protect our cells from carcinogenic influences.

A successful candidate holds a PhD and has experience in the following areas:
-human cell culture and basic cell-based techniques including siRNA-mediated gene knockdown, proliferation and survival assays, immunofluorescence analysis of protein localization.
-Basic molecular biology and proteomics techniques including cloning, PCR, subcellular fractionation, immunoprecipitation, and immunoblots
-Previous experience with human gene targeting would be an advantage
Applicants should be within 1-2 years of the time they obtained their PhD and must demonstrate a clear interest in pursuing an independent career in science.

Contact Information:
Alexandra Sobeck, Ph.D.
Assistant Professor
6-112 MCB
420 Washington Ave SE
Minneapolis, MN 55455
phone: 612-624-1343
fax: 612-625-2163
email: asobeck@umn.edu

Sobeck laboratory website: http://openwetware.org/wiki/Sobeck