Macromolecular Electron Microscopy (EM) Postdoctoral Opportunity at The Scripps Research Institute

The Asturias laboratory is looking for a motivated postdoctoral fellow interested in expanding his research experience to the application of single-particle electron microscopy (EM) to characterize the structure and conformational dynamics of macromolecular assemblies involved in transcription and chromatin structure regulation.

Working with us would provide state-of-the-art training in macromolecular EM and an opportunity for in-depth examination of the molecular mechanisms responsible for the regulation of gene expression. Candidates interested in our research and with previous experience in biochemistry, molecular, or structural biology are encouraged to apply (contact Francisco Asturias, asturias@scripps.edu).

Recent studies from our group are described in the following publications (see figure for a visual summary):

Cai, G., Imasaki, T., Yamada, K., Cardelli, F., Takagi, Y. and Asturias, F.J. 2010. Mediator Head module Structure and Functional Interactions. Nat Struct Mol Biol 17:273-279.
Cai, G., Imasaki, T., Takagi, Y. and Asturias, F.J. 2009. Mediator structural conservation and implications for the regulation mechanism. Structure 17:559-567.
Brignole, E.J., Smith, S., and Asturias, F.J. 2009. Conformational Flexibility of Metazoan Fatty Acid Synthase Enables Catalysis. Nat Struct Mol Biol 16:190-197.
Chaban, Y.L., Ezeokonkwo, C., Chung, W.H., Zhang, F., Kornberg, R.D., Maier-Davis, B., Lorch, Y., and Asturias, F.J. 2008. Structure of a RSC-Nucleosome Complex and Insights into Chromatin Remodeling. Nat Struct Mol Biol 15:1272-1277.