Wei Xuラボでは、ポスドクを募集しています。研究内容は、エストロゲンレセプターのコアクチベーターであるヒストンH3R17のメチルトランスフェラーゼCARM1に焦点をあて、その転写制御における役割を調べています。現在、Wei Xuラボ所属のポスドクが乳癌におけるCARM1の機能を解明し、Cancer Researchに投稿中です。今回の募集は、そのポスドクが帰国する為、その後を続けて研究して頂ける方を募集しています。
　もし、このラボに興味を持たれた方は、Weiに直接連絡を取って下さい。現地やラボの雰囲気などに関して、不安がある方は、私にまでメールでご連絡下さい。宜しくお願い致します。

Postdoctoral Position
Department of Oncology
McArdle Laboratory for Cancer Research
University of Wisconsin, Madison
U.S.A

A postdoctoral position is available immediately to study transcriptional regulation of estrogen receptor (ER) signaling pathways by nuclear receptor co-factors. At the cellular level, we are interested in understanding the molecular underpinnings of co-regulators’ action and biology in ER-involved processes, including cell proliferation, differentiation and cell cycle control. At the molecular level, we are exploring the molecular mechanisms whereby histone arginine methylation takes part in the epigenetic control of cancer cells (Recent publications: Kuhn, P. et al. Protein Science, (2009)18: 1272-1280; Powell E. and Xu, W. PNAS (2008), 105: 19012-19017; Higashimoto, K. et al., PNAS (2007) 104: 12318-12323). For additional information, see http://mcardle.oncology.wisc.edu/faculty/bio/xu_w.html. We recently found that CARM1, a histone arginine methyltransferase, could up-regulate ERα-mediated differentiation, suggesting that CARM1 is a unique activator for ER α and its enzymatic activity maybe therapeutic target in breast cancer (Mariam Al-Dhaheri et al., submitted to Cancer Research). Therefore, we will further study CARM1-mediated epigenetic changes using chromatin-immunoprecipitation coupled with sequencing (ChIP-seq) in cultured cancer cells and mice models. Candidate should have a Ph.D. or equivalent with a solid background in biochemistry and molecular biology. Familiarity with techniques in molecular biology, chromatin immunoprecipitation assay, and breast cancer mouse model is desirable. Candidate with his/her own funding is preferable but not mandatory. Highly motivated individuals should send curriculum vitae, a brief statement of research and career interests, and the names and contact information of three references by email to: Dr. Wei Xu (wxu@oncology.wisc.edu) or by Mail to: Department of Oncology, 1400 University Avenue, Madison, WI 53706-1599, U.S.A. Applications will be reviewed on an ongoing basis unti!
l position is filled.

Wei Xu (wxu@oncology.wisc.edu)
東元　健 (higashim@cc.saga-u.ac.jp)