A postdoctoral position is available at a NIH funded, newly established laboratory in the Baylor College of Medicine.
(http://www.bcm.edu/mcb/?PMID=7566)
(http://www.bcm.edu/urology/?pmid=12624)

MicroRNAs have been implicated in modulating the tumorigenic properties of cancer cells. Preliminary results in our laboratory demonstrated that two MicroRNAs transcribed in a cluster were overexpressed in human cancer stem cells. Forced expression of one MicroRNA in this cluster in a cancer cell line led to an enhancement of its tumorigenic property in vivo. The predicted targets for these MicroRNAs are two tumor suppressors, when inactivated, will lead to the activation of an oncoprotein that is also implicated in the self-renewal of stem cells.

The primary goal of this postdoctoral project is to elucidate the functional role of this MicroRNA cluster, to identify their targets and to examine their abilities in modulating self-renewal and tumorigenicity. Ideal candidate will be a self-motivated individual, with prior experiences in molecular biology and MicroRNA biology. Please send your cover letter stating your research goal, CV and contacts of three references (must include Ph.D. advisor and/or current advisor) to Dr Keith Syson Chan at kc1@bcm.edu.