Postdoctoral position

A postdoctoral position is available in a multidisciplinary team focused on “chemical biology and drug discovery”.
We aim to develop novel molecular entities that modulate cellular signaling pathways with an emphasis on protein-protein interactions (PPIs). PPIs play essential roles in virtually every biological process and thus are emerging as promising therapeutic targets for various diseases including cancer. However, it is very challenging to disrupt PPIs with small organic molecules because protein interaction interfaces are relatively large and shallow. To overcome this, we focus on the design and construction of various “peptidomimetic” (peptide-like molecules) libraries including peptoids. They are expected to be ideally suited molecules to target PPIs due to their relatively large size and biological stability against protease degradation. With these libraries in hand, we will perform high-throughput screens (either affinity based on-bead screens or multi-well plate based screens) to identify novel inhibitors of PPIs involved in cancer (Please see the papers below f!
or more details).
The position will work in a highly interactive and collaborative research environment to identify synthetic molecules through high-throughput screening and to study their biological and therapeutic potentials. We are seeking for a highly motivated candidate who has recent Ph.D. in biochemistry, molecular biology or a related discipline. An individual with experience in protein biochemistry, molecular biology and cell biology is preferred.
Please send your cover letter and CV with names of three references to Dr. Hyun-Suk Lim at limhyun@iupui.edu.

Web: http://www.medicine.iu.edu/body.cfm?id=8341&oTopID
References:
Lim et al. “Identification of a Peptoid Inhibitor of the Proteasome 19S Regulatory Particle” (2007) J. Am. Chem. Soc. 129, 7750 (http://pubs.acs.org/doi/abs/10.1021/ja072027p).
Lim et al. “Periodate-Triggered Cross-Linking Reveals Sug2/Rpt4 as the Molecular Target of a Peptoid Inhibitor of the 19S Proteasome Regulatory Particle” (2007) J. Am. Chem. Soc. 129, 12936 (http://pubs.acs.org/doi/abs/10.1021/ja075469%2B).