Postdoctoral Position for in Vivo studies of Lung Inflammation

We are looking for a postdoctoral fellow with a doctorate degree in Cellular/Molecular Biology, Immunology or Pathology to join a project on inflammation in the lung. Experience in working with mice is essential and with primary cells such as alveolar macrophages in tissue culture an advantage. Studies focus on mechanisms of inflammation that are mediated through the innate immune system using in vitro and in vivo techniques.

Inflammation of the lung is common and can lead to life-threatening complications. Our project focuses on cellular mechanisms in neutrophils, macrophages and endothelial cells that are responsible for the negative regulation of pro-inflammatory functions of these cells. Through gene targeting, we have generated mice that lack functional bcr and abr genes, which are negative regulators of the small GTPase Rac. These mice have a hyper-responsive innate immune system. We hope that ultimately this research will lead to the development of novel therapies to treat acute lung inflammation, chronic lung disease and sepsis.

Salary range for this position is from $40,000 depending upon experience, including fringe benefits. To apply, please send a resume including cover letter and two letters of reference to jgroffen@chla.usc.edu. We will only contact the most competitive candidates who provide all the necessary information.

For more information about CHLA go to the employer website. Also visit http://www.usc.edu/programs/pibbs/site/faculty/groffen_j.htm and http://www.usc.edu/programs/pibbs/site/faculty/heisterkamp_n.htm

Key words: Postdoctoral, knockout mice, innate immunity, lung, inflammation, macrophages, rac GTPases

Employer: Childrens Hospital Los Angeles (CHLA)

Company URL: http://www.childrenshospitalla.org

Location: 4650 Sunset Boulevard, Los Angeles CA 90027, USA