Post-doctoral Research in Functional Genomics and Super-Resolution imaging of Mitotic Processes.

A Postdoctoral position is available in Dr. Laurence Pelletier’s laboratory at the Samuel Lunenfeld Institute in the Mount Sinai Hospital in Toronto. Dr. Pelletier’s laboratory is keenly interested in the molecular mechanisms that govern various aspects of mitotic cell division including centrosome duplication, microtubule dynamics, mitotic spindle assembly and kinetochore function. Studies in the Pelletier lab revolve around cutting-edge microscopy techniques including FRAP/FLIM, 4-D multiplex time-lapse imaging and structured illumination (SI), functional genomics and high-content screening approaches in mammalian cells. In this position, the successful applicant will be part of a fast-paced dynamic and multi-disciplinary environment and play an integral role in novel and ongoing projects within the laboratory as well cementing collaborations with other labs.

The applicant should have experience in advanced light microscopy imaging systems, image analysis and statistical approaches to quantitative microscopy. Training in molecular and cell biology will be considered an asset.

Salary: 45,000 CAN$.

Selected Publications:

Lawo S, Bashkurov M, Mullin M, Ferreria MG, Kittler R, Habermann B, Tagliaferro A, Poser I, Hutchins JR, Hegemann B, Pinchev D, Buchholz F, Peters JM, Hyman AA, Gingras AC, Pelletier L. HAUS, the 8-Subunit Human Augmin Complex, Regulates Centrosome and Spindle Integrity. Curr Biol (2009).

Zhu, F., Lawo, S., Bird, A., Pinchev, D., Ralph, A., Richter, C., Müller-Reicher, T., Kittler, R., Hyman, A., Pelletier, L. The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis. Curr Biol. (2008).

Kittler, R., Pelletier, L., Heninger, AK., Slabicki, M., Theis, M., Miroslaw, L., Poser, I., Lawo, S., Grabner, H., Kozak, K., Wagner, J., Surendranath, V., Richter, C., Bowen, W., Jackson, AL., Habermann, B., Hyman, AA., Buchholz, F. Genome-scale RNAi profiling of cell division in human tissue culture cells. Nat Cell Biol (2007).

Pelletier, L., O'Toole, E.T., Schwager, A., Hyman, A.A. and Müller-Reichert, T. Centriole assembly in Caenorhabditis elegans. Nature (2006).

Pelletier, L., Özlü, N., Hannak, E., Cowan, C., Habermann, B., Ruer, M., Muller-Reichert, T. and Hyman, A.A. The Caenorhabditis elegans centrosomal protein SPD-2 is required for both pericentriolar material recruitment and centriole duplication. Curr Biol (2004).

For more information visit:

http://www.mshri.on.ca/pelletier/