Postdoctoral position available in protein degradation, stem cell, and cancer

Cancer Science Institute (CSI)-Singapore
National University of Singapore (NUS)

Regulated protein degradation plays crucial roles in many biological processes. De-regulation of protein degradation is frequently observed in human diseases including cancer.

The APC (anaphase promoting complex), an E3 ubiquitin ligase essential in regulating cell cycle, was first identified as a factor mediating mitotic Cyclin degradation. Recent studies have shown that the APC also mediates the degradation of proteins not related in function to mitosis in higher eukaryotes.

My group focuses on studying the molecular mechanism and physiological relevance of "non-canonical" APC-dependent protein degradation in multicellular organisms using both in vitro and in vivo systems (Wu Q, et al. Curr Biol. 17: 213-224, Araki M, et al. Genes Dev. 19: 2458-2465). In addition, we study the protein degradation pathways involved in tumorigenesis and development.

Experience in molecular and cell biology techniques as well as having strong communicative skills is advantageous. Candidates should submit a full CV with the names and contact information of three referees and a brief description of intent of research to Dr. Marito Araki, Cancer Stem Cell Program, Cancer Science Institute (CSI)-Singapore, National University of Singapore, Email: csima@nus.edu.sg