Positions for Postdoctoral Scientists in Tumour microenvironment

CR-UK, Stromal-tumour Interaction, Paterson Institute for Cancer Research, Manchester Cancer Research Centre, University of Manchester, UK (www.paterson.man.ac.uk.).

• Salary ranges from £25,500 – £38,000 dependent upon experience
• Immediate start available for this position

Research areas: tumour microenvironment, metastasis, stem cells, EMT(epithelial-mesencymal transition)

Co-ordination of involvement of stromal myofibroblasts in mammary tumour progression

Paterson/Manchester Cancer Research Centre is an actively growing cancer research institute and Manchester is getting the second biggest city in UK, attracting young people to live. A 3 year Postdoctoral Scientist position is available in the laboratory of Dr Akira Orimo to elucidate molecular mechanisms by which tumour microenvironment promotes carcinoma invasion and metastasis, especially, focusing on myofibroblasts, frequently recruited into invasive human epithelial carcinomas and involved in tumour progression.
We previously demonstrated that a large population of myofibroblasts, designated carcinoma-associated fibroblasts (CAFs), present within invasive human breast carcinomas exhibited an ability to promote carcinoma growth and angiogenesis. Thus, myofibroblast-secreted stromal cell-derived factor-1 (SDF-1)/CXCL12 chemokine mediated, in part, the tumour-promoting ability of these myofibroblasts by recruiting endothelial progenitor cells (EPCs) into tumour, boosting angiogenesis (Orimo A. et al, Cell, 121, 335-348, 2005; Orimo A. and Weinberg R.A., Cell Cycle, 5, 1597-1601, 2006).

Informal enquiries please contact via email on AOrimo@PICR.man.ac.uk

Akira Orimo. M.D., Ph.D.
Group Leader, CR-UK Stromal-Tumour Interaction
The Paterson Institute for Cancer Research,
The University of Manchester, UK
Phone:44-(0)161-446-3030
web: http://www.paterson.man.ac.uk/stromal/