本求人は候補者が決定したため募集を打ち切りました。This advertisement was withdrawn because the position has been filled.

A postdoctoral research fellow position is available immediately in the Mempel lab in the Center for Immunology and Inflammatory Diseases at the Massachusetts General Hospital/Harvard Medical School in the areas of T cell immunology, tumor biology, and in vivo imaging.

The Mempel Lab is studying the factors that control the effector function of CD8+ cytotoxic T lymphocytes (CTL) in peripheral tissues. A special focus is placed on the question how the interplay between CTL, T regulatory cells, and tumor-associated macrophages determines the outcome of anti-tumor immune responses. Our mainstay methodological approach is direct dynamic in vivo-visualization of immune cell behavior using intravital multiphoton microscopy in mice.

The successful candidate should have a background in basic immunology and substantial skills in standard methods of cellular immunology (e.g. flow cytometry, immunohistochemistry, primary cell culture) as well as molecular biology (e.g. molecular cloning, quantitative RT PCR). He should be ready to acquire skills and knowledge in advanced light microscopy and in microsurgery in mice.

For more information, please contact Thorsten Mempel (tmempel@mgh.harvard.edu).


A cover letter detailing research motivations and a curriculum vitae should be sent by email to the above address together with the names of three referees with contact information.



Thorsten R. Mempel, MD, PhD

Center for Immunology and Inflammatory Diseases
Massachusetts General Hospital

Harvard Medical School
Building 149 13th Street, Rm 8301
Boston, MA 02446
USA

For details of our work, please refer to:

Von Andrian UH and Mempel TR. Homing and cellular traffic in lymph nodes. Nat. Rev. Immunol. 2003; 3: 867-978.

Mempel TR, Henrickson SE, von Andrian UH. T cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 2004; 427: 154-159.

Mempel TR, Scimone ML, Mora JR, von Andrian UH. In vivo imaging of leukocyte trafficking in blood vessels and tissues. Curr. Opin. Immunol. 2004; 16: 406-417.

Sumen C, Mempel TR, Mazo IB, von Andrian UH. Intravital microscopy. Visualizing immunity in context. Immunity 2004; 21: 315-329.

Mempel TR, Pittet MJ*, Khazaie K, Weninger W, Weissleder R, Boehmer H, von Andrian UH. Regulatory T cells reversibly suppress CD8 killer cell function independent of effector differentiation. Immunity 2006; 25(1): 129-141.

Junt T, Moseman EA, Iannacone M, Massberg S, Lang PA, Boes M, Fink K, Henrickson ES, Shayakhmetov DM, Mempel TR, Whelan S, von Andrian UH: Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature 2007; 450:110-114

Henrickson SE, Mempel TR, Mazo IB, Liu B, Zheng H, Flynn M, Artyomov MN, Junt T, Wong, HC, Chakraborty AK, von Andrian UH: T cell sensing of antigen dose governs interactive behavior with APC – an integrative mechanism that sets a threshold for T cell activation. Nat. Immunol. 2008; Mar; 9(3):282-93

Pittet MJ, Mempel TR: Regulation of T Cell Migration and Effector Functions - Insights from in vivo imaging studies. Immunol. Rev. 2008; Feb; 221:107-29