Univ. of Alabama at Birmingham ポスドク募集のお知らせ

私の所属する講座のボスが、日本人のポスドクを探しております
興味をお持ちの方は、
Dr. Hengbin Wang に直接、メールにて連絡してください。
英語に不安のある方、もしくは日本語での質問のある方は
霜島（しもじま）宛に、メールをお願いします（pochiuab@uab.edu）
　
それではよろしくお願いします

Multiple Postdoctoral Researcher Positions Available

The organization and function of chromatin, the physiological template for all nuclear processes involving genetic information, are largely dictated by posttranslational histone modifications. Our laboratory has been focused on studying one of these modifications, histone ubiquitination. By following the enzymatic activities, we have recently identified several enzymes that are responsible for ubiquitination and deubiquitination of histone H3, H4, H2A, H2B, and H1. Further characterization indicates that these enzymes play critical roles in gene expression, cell cycle control, and DNA damage repair (see references). We are currently investigating the roles of these enzymes in stem cell function, embryogenesis, and cancer development. We employ a combination of biochemical and genetic approaches to decipher the functions of these histone modifying enzymes in chromatin and cellular regulation. People with strong interests in chromatin and epigenetic are encouraged to apply. Please send CV and the names of three references to:

Hengbin Wang, PhD
Department of Biochemistry and Molecular Genetics
The University of Alabama at Birmingham
Kaul Human Genetics Building, 402A
720 South 20th Street
Birmingham, AL 35294-0024
Tel: 205-934-5286 (O); 205-934-5289 (L)
Fax: 205-934-0758
E-mail: hbwang@uab.edu

Selected References:
1.　Hengbin Wang and Yi Zhang (2001). Mi2, an autoantigen for dermatomyositis, is an ATP-dependent nucleosome remodeling factor. Nuclei Acids Research, 29,2517-2521.
2.　Hengbin Wang, Zhiqing Huang, Li Xia, Qin Feng, Hediye Erdjument-Bromage, Brain D. Strahl, Scott Briggs, David C. Allis, Jiemin Wong, Paul Tempst, and Yi Zhang (2001). Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. Science, 293, 853-857.
3.　Hengbin Wang, Ru Cao, Li Xia, Hediye Erdjument-Bromage, Christoph Borchers, Paul Tempst, and Yi Zhang (2001). Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase. Molecular Cell, 8,1207-1217.
4.　Hengbin Wang, An Woojin, Ru Cao, Li Xia, Hediye Erdjument-Bromage, Bruno Chatton, Paul Tempst, Robert G. Roeder, and Yi Zhang (2003). mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. Molecular Cell, 12 (2), 475-487.
5.　Hengbin Wang, Liangjun Wang, Migual Vadel, Hediye Erdjument-Bromage, Paul Tempst, Richard S. Hones, and Yi Zhang (2004). Role of H2A ubiquitination in Polycomb gene silencing. Nature 431:873-878.
6.　Hengbin Wang*, Ling Zhai, Jun Xu, Heui-Yoo Joo, Sarah Jackson, Hediye Erdjument-Bromage, Paul Tempst, Yue Xiong, and Yi Zhang*. (2006). Histones H3 and H4 ubiquitylation by the Cul4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. Molecular Cell. 22(3):383-394. (*co-correspondence author).
7.　Jianhua Wei, Ling Zhai, Jun Xu, and Hengbin Wang. (2006). Role of Bmi1 in H2A Ubiquitylation and Hox Gene Silencing, Journal of Biological Chemistry, Aug 11;281(32):22537-44.
8.　Heui-Yoo Joo, Ling Zhai, Chunying Yang, Shui Nie, Hediye Erdjument-Bromage, Paul Tempst, and Chenbei Chang, Hengbin Wang. (2007) Regulation of cell cycle progression and gene expression by H2A deubiquitination. Nature, Oct 25;449(7165):1068-72.

Complete publication list of Dr. Hengbin Wang can be found in PubMed.