本求人は候補者が決定したため募集を打ち切りました。This advertisement was withdrawn because the position has been filled.

Samuel Lunenfeld Research Institute in Toronto, Canada ポスドク募集

Dr. Daniel Durocherのラボでは，DNA損傷修復，細胞周期チェックポイントもしくはテロメア関連の研究に従事してくださるポスドクフェローを募集しています．

Durocherラボの主たる研究テーマは， DNA損傷修復，細胞周期チェックポイントおよびテロメア維持に関連する新規遺伝子の同定解析です．アプローチの手段として，酵母と哺乳類培養細胞の両方を用いています．最近はhuman genomeのsiRNAライブラリを利用したスクリーニングに力を入れています．このアプローチにより，Durocherラボでは，RNF8がDNA damage responseに重要なE3 ユビキチンライゲースであることを発見しました．

応募資格:
Cell biology, molecular biology もしくは protein biochemistryのいずれかに精通している方．テロメア，DNA損傷修復，細胞周期チェックポイント，V(D)J recombination, class switch recombination，減数分裂の研究に経験のある方は，優先される可能性があります．

応募方法:
履歴書とともに興味のある研究とこれまでの研究経験を記載した書類（PDF形式もしくはWord形式）をe-mailでご送信ください．
宛先: durocher@mshri.on.ca

応募前にご質問がありましたら，投稿者までお気軽にご連絡ください．

A postdoctoral position is available in the area of DNA repair, checkpoint signaling, or telomere biology in the laboratory of Dr. Daniel Durocher at the Samuel Lunenfeld Research Institute in Toronto, Canada.

A major effort of the Durocher laboratory is to discover and characterize novel genes involved in DNA repair, checkpoint signaling or telomere biology. The Durocher lab employs both yeast and mammalian systems but a recent emphasis has been on utilizing RNA interference technology to screen the human genome for novel genes modulating the DNA damage response. An example of the successful use of this approach is our recent discovery of RNF8, an E3 ubiquitin ligase that acts to promote the localization of 53BP1 and BRCA1 to sites of DNA lesions (see Kolas et al. Science 318: 1637 2007).

Candidates must have a strong background in at least one of the following areas: cell biology, molecular biology or protein biochemistry. Demonstrated interest in telomere, DNA repair, checkpoint or chromatin biology is an advantage. Candidates also working on V(D)J, class switch or meiotic recombination are also strongly encouraged to apply.

Motivated candidates should send a description of research interest and experience as well as curriculum vitae. Please send PDF or Word files by e-mail to: durocher@mshri.on.ca.

Toronto is a vibrant cosmopolitan city at the heart of North America. The Samuel Lunenfeld Research Institute, where the Durocher laboratory is located is one of the premier research Institutes in North America and is host to many Japanese post-doctoral fellows. Toronto is a safe city with excellent schools and is routinely placed in the top 10 cities in the world in terms of quality of life.
Selected references from the Durocher lab:

Kolas NK et al. Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science. 2007 Dec 7;318(5856):1637-40.

Downey M et al. A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator. Cell. 2006 Mar 24;124(6):1155-68.

Downey M, Durocher D. Chromatin and DNA repair: the benefits of relaxation. Nat Cell Biol. 2006 Jan;8(1):9-10.

Keogh MC et al. A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature. 2006 Jan 26;439(7075):497-501.