現在、私どものラボ（Dr. Mark Bix）では、ポスドクを募集しております。
興味を持たれた方は、Dr.Bix　(mark.bix@stjude.org)　までお問い合わせください。
日本語での問い合わせは、madoka.koyanagi@stjude.orgにお願いいたします。

The Bix lab studies the development and function of CD4 T cells. The lab uses genetic, cellular, biochemical and organismic approaches to understand how different subsets of effector T cells arise from a common “nai¨ve” progenitor and how the immune response is affected when this process is perturbed. Toward this end, the recent focus has been on the developmental regulation of cytokine genes that are differentially expressed in distinct effector T cell subsets.
The qualified candidate will pursue transgenic approaches to targeting transcription factors to specific genetic loci in order to perform functional analyses. Immunological experience is not required. However, individuals with expertise in molecular biology, protein biochemistry and gene targeting will be favored.

Baguet, A., Epler, J., Wa-Wen, K. and Bix, M. (2004) A Leishmania major resistance locus identified by interval-specific congenic mapping of a TH2 bias controlling QTL. J. Exp. Med. 200:1605-1611.

Bix, M., Kim, S. and Rao, A. (2005) Opposites attract: cytokine transcription in differentiating T cells. Science 308:1563-1565.

Koyanagi, M., Baguet, A., Martens, J., Margueron, R., Jenuwein, T. and Bix, M. (2005) EZH2 and H3-tri-methyl lysine 27 associated with Il4 and Il13 gene silencing in TH1 cells. J Biol Chem. 280:31470-31477.

Baguet, A., Sun, X., Arroll, T., Krumm, A. and Bix, M. (2005) Intergenic transcription is not required in TH2 cells to maintain histone acetylation and transcriptional permissiveness at the Il4-Il13 locus. Journal of Immunology. 175:8146-8153.

Please submit a CV, research summary and 3 references.

Mark Bix, Ph.D.
Assistant Member
Immunology Department
St. Jude Children’s Research Hospital
MS #351, 570 St. Jude Place, Room E7064
Memphis, TN 38105